MOENOMYCIN .7. ISOLATION AND PROPERTIES OF FURTHER COMPONENTS OF ANTIBIOTIC MOENOMYCIN

被引：12
作者：
SCHACHT, U
HUBER, G
机构：
[1] Farbwerke Hoechst AG., Frankfurt am Main
来源：
JOURNAL OF ANTIBIOTICS | 1969年 / 22卷 / 12期
关键词：
D O I：
10.7164/antibiotics.22.597
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The new antibiotic, moenomycin, isolated from Streptomyces bambergiensis is a mixture of several, chemically very similar components, which are particularly characterized by their phosphorus content. The moenomycin complex can be separated into components A, B1, B2 and C by means of column chromatography on silica gel with n-propanol - 2N ammonia as eluant. The use of other chromatographic procedures, e. g. chromatography on anion exchange resins, results in a further separation of fraction B1 into components D, E and F; similarly fraction B2 can be separated into components G and H. Isolation and properties of moenomycins D, E, F, G and H are described. © 1969, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
引用
收藏
页码：597 / &
相关论文
共 50 条
  • [21] LINKAGE OF MOENOCINOL, GLYCERIC ACID AND PHOSPHORIC-ACID IN ANTIBIOTIC, MOENOMYCIN A
    WELZEL, P
    WITTELER, FJ
    MULLER, D
    TETRAHEDRON LETTERS, 1976, (20) : 1665 - 1668
  • [22] THE 1ST ENZYMATIC DEGRADATION PRODUCTS OF THE ANTIBIOTIC MOENOMYCIN-A
    METTEN, KH
    HOBERT, K
    MARZIAN, S
    HACKLER, UE
    HEINZ, U
    WELZEL, P
    ARETZ, W
    BOTTGER, D
    HEDTMANN, U
    SEIBERT, G
    MARKUS, A
    LIMBERT, M
    VANHEIJENOORT, Y
    VANHEIJENOORT, J
    TETRAHEDRON, 1992, 48 (39) : 8401 - 8418
  • [23] A STRUCTURALLY AND BIOGENETICALLY INTERESTING MOENOMYCIN ANTIBIOTIC (VOL 51, PG 1931, 1995)
    DONNERSTAG, A
    MARZIAN, S
    MULLER, D
    WELZEL, P
    BOTTGER, D
    STARK, A
    FEHLHABER, HW
    MARKUS, A
    VANHEIJENOORT, Y
    VANHEIJENOORT, J
    TETRAHEDRON, 1995, 51 (19) : 5509 - 5509
  • [24] Synthesis of a complex disaccharide precursor of phosphonate analogues of the antibiotic moenomycin A12
    Abu Ajaj, K
    Hennig, L
    Findeisen, M
    Giesa, S
    Müller, D
    Welzel, P
    TETRAHEDRON, 2002, 58 (42) : 8439 - 8451
  • [25] Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design
    Yuan, Yanqiu
    Fuse, Shinichiro
    Ostash, Bohdan
    Sliz, Piotr
    Kahne, Daniel
    Walker, Suzanne
    ACS CHEMICAL BIOLOGY, 2008, 3 (07) : 429 - 436
  • [26] Isolation and structural elucidation of AC326-α, a new member of the moenomycin group
    He, HY
    Shen, B
    Korshalla, J
    Siegel, MM
    Carter, GT
    JOURNAL OF ANTIBIOTICS, 2000, 53 (02) : 191 - 195
  • [27] Moenomycin A: New chemistry that allows to attach the antibiotic to reporter groups, solid supports, and proteins
    Kempin, U
    Hennig, L
    Knoll, D
    Welzel, P
    Muller, D
    Markus, A
    vanHeijenoort, J
    TETRAHEDRON, 1997, 53 (52) : 17669 - 17690
  • [28] Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin
    Makitrynskyy, Roman
    Ostash, Bohdan
    Tsypik, Olga
    Rebets, Yuriy
    Doud, Emma
    Meredith, Timothy
    Luzhetskyy, Andriy
    Bechthold, Andreas
    Walker, Suzanne
    Fedorenko, Victor
    OPEN BIOLOGY, 2013, 3 (10): : 130121
  • [29] Studies on the interaction of the antibiotic moenomycin A with the enzyme penicillin-binding protein 1b
    Rühl, T
    Daghish, M
    Buchynskyy, A
    Barche, K
    Volke, D
    Stembera, K
    Kempin, U
    Knoll, D
    Hennig, L
    Findeisen, M
    Oehme, R
    Giesa, S
    Ayala, J
    Welzel, P
    BIOORGANIC & MEDICINAL CHEMISTRY, 2003, 11 (13) : 2965 - 2981
  • [30] STRUCTURAL ANALOGS OF THE ANTIBIOTIC MOENOMYCIN-A WITH A D-GLUCOSE-DERIVED UNIT-F
    HEUER, M
    HOHGARDT, K
    HEINEMANN, F
    KUHNE, H
    DIETRICH, W
    GRZELAK, D
    MULLER, D
    WELZEL, P
    MARKUS, A
    VANHEIJENOORT, Y
    VANHEIJENOORT, J
    TETRAHEDRON, 1994, 50 (07) : 2029 - 2046
12345