ASCORBIC-ACID MODULATION OF SPLENIC CELL CYCLIC-GMP METABOLISM

被引:2
|
作者
HADDOX, MK
STEPHENSON, JH
MOSER, ME
GLASS, DB
WHITE, JG
HOLMESGRAY, B
GOLDBERG, ND
机构
[1] UNIV MINNESOTA,LAB MED LAB,MINNEAPOLIS,MN 55455
[2] UNIV MINNESOTA,DEPT PATHOL,MINNEAPOLIS,MN 55455
基金
美国国家卫生研究院;
关键词
D O I
10.1016/0024-3205(79)90016-X
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Chronic ascorbate deprivation of guinea pigs decreased splenic cell cyclic GMP levels (80%); ascorbate (1 mM) addition to these cells in vitro restored the cellular concentration to control levels. Splenic cells from non-scorbutic animals also exhibited increases in cyclic GMP levels in response to exogenous ascorbate whereas thiol reducing agents diminished cellular cyclic GMP concentration. Agents that inhibit the propagation of free radicals prevented this cellular effect of ascorbate while agents known to interfere with or promote H2O2 production had no effect. Guanylate cyclase activity in cell lysates increased after treatment of intact cells with ascorbate; dithiothreitol reversed this effect. Ascorbate also enhanced guanylate cyclase activity in cell lysates. The results suggest that oxidizing equivalents in the form of the monoanionic free radical of ascorbate alter cyclic GMP metabolism in these cells by activating guanylate cyclase via a mechanism involving oxidation of a cyclase-related component. © 1979.
引用
收藏
页码:1555 / 1566
页数:12
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