Association of the CTLA4 gene CT60/rs3087243 single-nucleotide polymorphisms with Graves' disease

被引：19

作者：

Fang, Weizhen ^{[1
]}

Zhang, Zhixian ^{[1
]}

Zhang, Jin ^{[2
]}

Cai, Zhenhua ^{[3
]}

Zeng, Hua ^{[1
]}

Chen, Mei ^{[1
]}

Huang, Junqi ^{[4
]}

机构：

[1] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Clin Lab, Guangzhou 510120, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Endocrinol, Guangzhou 510120, Guangdong, Peoples R China

[3] Guangzhou Univ Tradit Chinese Med, Dept Clin Lab, Affiliated Hosp 1, Guangzhou 510405, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Immunol, 74 Zhongshan 2nd Rd, Guangzhou 510080, Guangdong, Peoples R China

来源：

BIOMEDICAL REPORTS | 2015年 / 3卷 / 05期

关键词：

Graves' disease; cytotoxic T lymphocyte-associated 4; CT60; single-nucleotide polymorphism;

D O I：

10.3892/br.2015.493

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

It has been widely reported that the CT60 single-nucleotide polymorphism (SNP), which is in the 3'-untranslated region of the cytotoxic T lymphocyte associated 4 (CTLA4) gene, is strongly correlated with certain immune-mediated diseases. The present case-control study aimed to investigate the genetic association between the CT60 SNP within the CTLA4 gene and Graves' disease (GD). A total of 288 patients with GD and 290 control subjects were recruited for the study. The CT60 SNP of the CTLA4 gene was detected by direct DNA sequencing. The results indicated that the frequencies of the GG genotype and G allele in the case group were evidently higher than that in the control group (P= 4x10(-6) and P= 2.9x10(-5), respectively). Furthermore, the G/G genotype of the CT60 SNP was associated with an increased risk for GD (odds ratio= 2.223). In conclusion, these results suggested that the CT60 SNP is associated with susceptibility to GD. The frequency of the disease-susceptible G allele of CT60 was significantly associated with an increased risk of GD development.

引用

页码：691 / 696

页数：6

共 41 条

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