MONOGLUCOSYLATION OF LOW-MOLECULAR-MASS GTP-BINDING RHO PROTEINS BY CLOSTRIDIAL CYTOTOXINS

被引：72

作者：

AKTORIES, K

JUST, I

机构：

来源：

TRENDS IN CELL BIOLOGY | 1995年 / 5卷 / 12期

关键词：

D O I：

10.1016/S0962-8924(00)89107-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Rho proteins, which are involved in receptor-mediated regulation of the actin cytoskeleton, are substrates for ADP-ribosylation by Clostridium botulinum C3 toxins. Recently, it was shown that Rho and other members of the Rho subfamily of low-molecular-mass GTP-binding proteins are glucosylated by C. difficile toxins A and B. Glucosylation occurs at threonine-37, which is a crucial amino acid residue for the regulatory functions of the small GTP-binding proteins. These toxins should prove useful as tools for studying the functions of Rho proteins.

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页码：441 / 443

页数：3

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