STUDIES ON THE ENANTIOSPECIFIC SYNTHESIS OF OXINDOLE ALKALOIDS

被引：25

作者：

PETERSON, AC ^{[1
]}

COOK, JM ^{[1
]}

机构：

[1] UNIV WISCONSIN,DEPT CHEM,MILWAUKEE,WI 53201

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 17期

关键词：

D O I：

10.1016/S0040-4039(00)76997-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The optically active N-a-methyl, N-b-benzyltetracyclic ketone 1 was converted into either diastereomeric spirocyclic oxindole 2a (91:9) or 2b (97:3) with high diastereoselectivity on prudent choice of osmium reagents. Oxindole 2a is now available in enantiospecific form for the synthesis of Alstonia alkaloids while diastereomer 2b can be employed for the preparation of Gardneria and Voacanga bases.

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页码：2651 / 2654

页数：4

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