CANNABINOID RECEPTOR AGONISTS INHIBIT CA CURRENT IN NG108-15 NEUROBLASTOMA-CELLS VIA A PERTUSSIS TOXIN-SENSITIVE MECHANISM

被引：217
作者：
CAULFIELD, MP
BROWN, DA
机构：
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 1992年 / 106卷 / 02期
关键词：
CANNABINOID; G-PROTEIN; PERTUSSIS TOXIN; CALCIUM CURRENT; NEUROBLASTOMA;
D O I：
10.1111/j.1476-5381.1992.tb14321.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cannabinoid receptor ligands irreversibly inhibited peak voltage-activated Ca currents (44%) in NG108-15 cells; this inhibition was Pertussis toxin-sensitive. Inhibition was largely due to a reduction in the omega-conotoxin sensitive portion of high-voltage activated (HVA) current, although there was also a significant decrease in low-voltage activated current (56%) and in the nifedipine-sensitive portion of HVA current (41%).
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页码：231 / 232
页数：2
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