Animal Models for Fibrotic Liver Diseases: What We Have, What We Need, and What Is under Development

被引：123
作者：
Delire, Benedicte [1 ]
Starkel, Peter [1 ,2 ,3 ]
Leclercq, Isabelle [1 ]
机构：
[1] Catholic Univ Louvain UCL, IREC, Lab Hepatogastroenterol, Ave E Mounier 53,Box B1-52-01, B-1200 Brussels, Belgium
[2] Catholic Univ Louvain, St Luc Acad Hosp, Dept Gastroenterol, Brussels, Belgium
[3] Catholic Univ Louvain, Inst Clin Res, Brussels, Belgium
来源：
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY | 2015年 / 3卷 / 01期
关键词：
Liver; Fibrosis; Hepatic stellate cell; Animal models; Cell tracking;
D O I：
10.14218/JCTH.2014.00035
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Liver fibrosis is part of the wound-healing response to liver damage of various origins and represents a major health problem. Although our understanding of the pathogenesis of liver fibrosis has grown considerably over the last 20 years, effective antifibrotic therapies are still lacking. The use of animal models is crucial for determining mechanisms underlying initiation, progression, and resolution of fibrosis and for developing novel therapies. To date, no animal model can recapitulate all the hepatic and extra-hepatic features of liver disease. In this review, we will discuss the current rodent models of liver injuries. We will then focus on the available ways to target specifically particular compounds of fibrogenesis and on the new models of liver diseases like the humanized liver mouse model. (C) 2015 The Second Affiliated Hospital of Chongqing Medical University. Published by XIA & HE Publishing Ltd. All rights reserved.
引用
收藏
页码：53 / 66
页数：14
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