HEPATOCYTE GROWTH-FACTOR IS A POTENT STIMULATOR OF HUMAN MELANOCYTE DNA-SYNTHESIS AND GROWTH

被引：217
作者：
MATSUMOTO, K
TAJIMA, H
NAKAMURA, T
机构：
[1] Department of Biology, Faculty of Science, Kyushu University, Fukuoka
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 176卷 / 01期
关键词：
D O I：
10.1016/0006-291X(91)90887-D
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hepatocyte growth factor (HGF) is a potent mitogen for adult rat hepatocytes in primary culture. HGF stimulates growth and DNA synthesis of normal human epidermal melanocytes in culture. The maximal stimulation of DNA synthesis by 4.0-fold occurred with 10 ng/ml HGF. This stimulatory effect was additive with both acidic and basic fibroblast growth factors, while it was inhibited by transforming growth factor-β1. Melanocytes expressed a single class of specific, high-affinity receptors for HGF with a Kd of 22 pM and approximately 120 receptors/cell. Thus, HGF is a potent mitogen for normal human epidermal melanocytes. © 1991.
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页码：45 / 51
页数：7
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