Nano Drug Delivery Study of Anticancer Properties on Ginger using QM/MM Methods

Ginger is a one of the most important foods which as an anticancer drug. It is well-known for its ability to shrink tumors. The anti-cancer properties were observed in addition to ginger's role in reducing inflammation, as well as being a rich source of life-enhancing antioxidants. Ginger has long been used in traditional medicine as a cure for some diseases including inflammatory diseases(1).Ginger contains active phenolic compounds such as gingerol, paradol and shogaol that have antioxidant(2),anti-cancer(3), anti-inflammatory(4), anti-angiogenesis(5) and anti-artherosclerotic properties(6) (Fig.2). In the present work, we investigated the potential anti-inflammatory and anticancer effects of ginger extract including gingerol, andshogaol jointed to nanotubeas dug delivery technics. So, we have used Gussian 98 methods for calculation via (B3LYP-MP2-) with 6-31g*, basis sets We has also studied NMR by changing the substituents in ginger for analyzing its properties.