USE OF IPRATROPIUM BROMIDE NASAL SPRAY IN CHRONIC TREATMENT OF NONALLERGIC PERENNIAL RHINITIS, ALONE AND IN COMBINATION WITH OTHER PERENNIAL RHINITIS MEDICATIONS

被引：37

作者：

GROSSMAN, J

BANOV, C

BOGGS, P

BRONSKY, EA

DOCKHORN, RJ

DRUCE, H

FINDLAY, SR

GEORGITIS, JW

HAMPEL, FC

KAISER, H

RATNER, P

TINKELMAN, DG

VALENTINE, MD

ROSZKO, P

ZEGARELLI, E

WOOD, C

机构：

[1] Albany, N.Y., Charleston, S.C., Shreveport, La., Salt Lake City, Utah, Prairie Village, Kan., St. Louis, Mo., Austin, Texas, Winston-Salem, N.C., New Braunfels, Texas, Minneapolis, Minn., San Antonio, Texas, Atlanta, Ga., Baltimore, Md., and Ridgefield

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 1995年 / 95卷 / 05期

关键词：

NONALLERGIC RHINITIS; IPRATROPIUM; NASAL SPRAY; SAFETY; EFFICACY CHRONIC;

D O I：

10.1016/S0091-6749(95)70216-4

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

To study the long-term safety and effectiveness of ipratropium bromide nasal spray 0.03% in the treatment of nonallergic perennial rhinitis, we administered this medication for 1 year in an open-label trial involving 285 patients. Our intention was to maintain the highest protocol dose possible to gain a clearer picture of the long-term side effect profile of the compound. Ipratropium bromide was well tolerated with no serious side effects in this patient population. It provided a significant improvement in rhinorrhea throughout the year-long trial; only 17 of 285 patients (6%) were considered treatment failures. There was an improvement in patient quality of life, as well as a substantial reduction in the need for other medications(antihistamines, decongestants, and nasal steroids) used to treat perennial rhinitis symptoms.

引用

页码：1123 / 1127

页数：5