ABNORMALITIES OF THE AUTONOMIC NERVOUS-SYSTEM OF THE DUODENUM IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

被引：0
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作者：
KAMATA, K
SAKAMOTO, A
KASUYA, Y
机构：
来源：
RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY | 1992年 / 75卷 / 03期
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R36 [病理学];
学科分类号：
100104 ;
摘要：
The changes in sensitivity of the rat duodenum to ATP were examined in preparations from control rats and from rats with streptozotocin (STZ)-induced diabetes. ATP was able to relax the duodenum of control animals in a concentration-dependent manner and this relaxation was significantly increased in STZ-diabetic rats. In preparations from diabetic rats, relaxation responses to ATP were greater than those of age-matched control groups. These results suggest that functional changes or degeneration of non-adrenergic, non-cholinergic nerves in the myenteric plexus may occur in STZ-diabetic rats, and that these alterations may result in the increased sensitivity of the relaxation of the duodenum to ATP.
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页码：361 / 364
页数：4
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