FROM NUCLEIC-ACIDS TO PROTEINS

被引：0
作者：
IKEHARA, M
机构：
来源：
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 1991年 / 111卷 / 03期
关键词：
GENETIC INFORMATION; PROTEIN ENGINEERING; H-LYSOZYME; RIBONUCLEASE H; DENOVO PROTEIN;
D O I：
10.1248/yakushi1947.111.3_170
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Since elucidation of structure of deoxyribonucleic acid (DNA) as genetic material, it was established that DNA makes ribonucleic acid, which makes protein according to the original information given in DNA base as base sequences. From these basic idea of genetic flow system there was emerged the word "protein engineering". According to this principle, engineering of h-lysozyme, RNase H and their relevant proteins was described. A triosephosphate isomerase barrel type protein was designed and expressed.
引用
收藏
页码：170 / 181
页数：12
相关论文
共 11 条
[1]   DESIGN AND SYNTHESIS OF A PEPTIDE HAVING CHYMOTRYPSIN-LIKE ESTERASE-ACTIVITY [J].
HAHN, KW ;
KLIS, WA ;
STEWART, JM .
SCIENCE, 1990, 248 (4962) :1544-1547
[2]   SYNTHESIS AND HYBRIDIZATION STUDIES ON 2 COMPLEMENTARY NONA(2'-O-METHYL)RIBONUCLEOTIDES [J].
INOUE, H ;
HAYASE, Y ;
IMURA, A ;
IWAI, S ;
MIURA, K ;
OHTSUKA, E .
NUCLEIC ACIDS RESEARCH, 1987, 15 (15) :6131-6148
[3]   ROLE OF CYSTEINE RESIDUES IN RIBONUCLEASE-H FROM ESCHERICHIA-COLI - SITE-DIRECTED MUTAGENESIS AND CHEMICAL MODIFICATION [J].
KANAYA, S ;
KIMURA, S ;
KATSUDA, C ;
IKEHARA, M .
BIOCHEMICAL JOURNAL, 1990, 271 (01) :59-66
[4]  
KANAYA S, 1989, J BIOL CHEM, V264, P11546
[5]  
KANAYA S, 1990, J BIOL CHEM, V265, P4615
[6]   3-DIMENSIONAL STRUCTURE OF RIBONUCLEASE-H FROM ESCHERICHIA-COLI [J].
KATAYANAGI, K ;
MIYAGAWA, M ;
MATSUSHIMA, M ;
ISHIKAWA, M ;
KANAYA, S ;
IKEHARA, M ;
MATSUZAKI, T ;
MORIKAWA, K .
NATURE, 1990, 347 (6290) :306-309
[7]   DESIGN AND CREATION OF A CA-2+ BINDING-SITE IN HUMAN LYSOZYME TO ENHANCE STRUCTURAL STABILITY [J].
KUROKI, R ;
TANIYAMA, Y ;
SEKO, C ;
NAKAMURA, H ;
KIKUCHI, M ;
IKEHARA, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (18) :6903-6907
[8]  
TANIYAMA T, 1988, BIOCHEM BIOPH RES CO, V152, P962
[9]   ENGINEERING OF THE HYDROPHOBIC SEGMENT OF THE SIGNAL SEQUENCE FOR EFFICIENT SECRETION OF HUMAN LYSOZYME BY SACCHAROMYCES-CEREVISIAE [J].
YAMAMOTO, Y ;
TANIYAMA, Y ;
KIKUCHI, M ;
IKEHARA, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 149 (02) :431-436
[10]   CONFORMATIONAL REQUIREMENT OF SIGNAL SEQUENCES FUNCTIONING IN YEAST - CIRCULAR-DICHROISM AND H-1 NUCLEAR-MAGNETIC-RESONANCE STUDIES OF SYNTHETIC PEPTIDES [J].
YAMAMOTO, Y ;
OHKUBO, T ;
KOHARA, A ;
TANAKA, T ;
TANAKA, T ;
KIKUCHI, M .
BIOCHEMISTRY, 1990, 29 (38) :8998-9006
12