HEMOGLOBIN LEPORE TRAIT - HEMATOLOGICAL AND STRUCTURAL STUDIES ON THE ITALIAN POPULATION

被引：23

作者：

MARINUCCI, M ^{[1
]}

MAVILIO, F ^{[1
]}

MASSA, A ^{[1
]}

GABBIANELLI, M ^{[1
]}

FONTANAROSA, PP ^{[1
]}

SAMOGGIA, P ^{[1
]}

TENTORI, L ^{[1
]}

机构：

[1] IST SUPER SANITA, REFERENCE CTR HAEMOGLOBINOPATH & THALASSAEMIAS, PATOL INFETTIVA LAB, I-00161 ROME, ITALY

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1979年 / 42卷 / 04期

关键词：

D O I：

10.1111/j.1365-2141.1979.tb01168.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hematological data on 59 heterozygotes for Hb Lepore and 10 double heterozygotes for Hb Lepore and .beta.-thalassemia from 36 Italian families are reported. The red cell indices are defined and compared with those of groups of non-thalassemic and .beta.-thalassemic subjects of comparable number, age and sex distribution. The relative level of each Hb fraction and the absolute production of single polypeptide chains are calculated in order to compare the expression of the non-.alpha. chain genes in Hb Lepore trait and .beta.-thalassemia. Structural studies demonstrate that the Hb Lepore is of the Boston type (.delta.87 .beta.116) in all subjects, confirming that this type of fusion variant is probably the only one which occurs in Mediterranean populations. The distribution and incidence of the Lepore hemoglobinopathy are discussed.

引用

页码：557 / 565

页数：9

共 50 条

[31] Hematological, Biochemical Properties, and Clinical Correlates of Hemoglobin S Variant Disorder: A New Insight Into Sickle Cell Trait
Khaled, Safaa A. A.
Ahmed, Heba A.
Elbadry, Mahmoud, I
NasrEldin, Eman
Hassany, Sahar M.
Ahmed, Shimaa A.
JOURNAL OF HEMATOLOGY, 2022, 11 (03) : 92 - 108
[32] STRUCTURAL STUDIES OF INVITRO ALKYLATION OF HEMOGLOBIN BY ELECTROPHILIC METABOLITES
KAUR, S
HOLLANDER, D
HAAS, R
BURLINGAME, AL
ACS SYMPOSIUM SERIES, 1990, 420 : 270 - 285
[33] STRUCTURAL AND BIOSYNTHETIC STUDIES ON HEMOGLOBIN-A1C
HANEY, DN
BUNN, HF
KAMEN, S
GABBAY, K
GALLOP, PM
BLOOD, 1975, 46 (06) : 1051 - 1051
[34] STRUCTURAL STUDIES OF HAPTOGLOBINS .3. INTERACTIONS WITH HEMOGLOBIN
WAKS, M
ALFSEN, A
SCHWAIGER, S
MAYER, A
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1969, 132 (01) : 268 - +
[35] HEMATOLOGICAL STUDIES IN HEMOGLOBIN SO ARAB AND CO ARAB DISEASES - CLINICAL AND LABORATORY EVALUATION
KINI, KR
WARRIER, RP
MAEDA, K
REBUCK, J
RUCKNAGEL, DL
PEDIATRIC RESEARCH, 1981, 15 (04) : 580 - 580
[36] HEMATOLOGICAL STUDIES ON WILD BLACK RHINOCEROS (DICEROS-BICORNIS) - EVIDENCE OF AN UNSTABLE HEMOGLOBIN
PAUL, B
DUTOIT, R
LLOYD, S
MANDISODZA, A
JOURNAL OF ZOOLOGY, 1988, 214 : 399 - 405
[37] HEMATOLOGICAL ASPECTS OF ARSENIC METABOLISM .I. GEL FILTRATION STUDIES WITH RAT HEMOGLOBIN
STORY, GE
FEDERATION PROCEEDINGS, 1964, 23 (2P1) : 199 - &
[38] HEMATOLOGICAL STATUS OF CENTRAL-AMERICAN POPULATION - PREVALENCE OF INDIVIDUALS WITH HEMOGLOBIN LEVELS BELOW NORMAL
VITERI, FE
GUZMAN, MA
BRITISH JOURNAL OF HAEMATOLOGY, 1972, 23 (06) : 725 - 735
[39] Tradition, modernity, and Italian babies (Population studies)
Miller, P
HISTOIRE SOCIALE-SOCIAL HISTORY, 2002, 35 (69): : 195 - 233
[40] Functional and structural properties of the hemoglobin components from Italian sturgeon (Acipenser naccarii)
Clementi, ME
De Rosa, MC
Bertonati, C
Capo, C
Cataldi, E
Petruzzelli, R
Giardina, B
FISH PHYSIOLOGY AND BIOCHEMISTRY, 2001, 24 (03) : 191 - 200

← 1 2 3 4 5 →