SESQUITERPENE LACTONES AND OTHER CONSTITUENTS FROM A CYTOTOXIC EXTRACT OF MICHELIA-FLORIBUNDA

被引：18
作者：
MONDRANONDRA, IO
CHE, CT
RIMANDO, AM
VAJRODAYA, S
FONG, HHS
FARNSWORTH, NR
机构：
[1] UNIV ILLINOIS,COLL PHARM,PHARMACEUT SCI,PROGRAM COLLABORAT RES,POB 6998,CHICAGO,IL 60680
[2] CHULALONGKORN UNIV,FAC PHARMACEUT SCI,DEPT PHARMACEUT BOT,BANGKOK 5,THAILAND
来源：
PHARMACEUTICAL RESEARCH | 1990年 / 7卷 / 12期
关键词：
cytotoxicity test; dihydroreynosin glucoside; dihydrotamaulipin A glucoside; isolation; Magnoliaceae; Michelia floribunda; sesquiterpene lactones;
D O I：
10.1023/A:1015937921880
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The pentane and CHC13 fractions of a crude extract of Michelia floribunda exhibited cytotoxic activity when tested in KB and P388 tumor cell cultures. Repeated chromatography led to the isolation of three cytotoxic sesquiterpene lactones (costunolide, parthenolide, and santamarine) and a cytotoxic isoquinoline alkaloid (liriodenine). Inactive sesquiterpene lactones obtained during the course of this study included dihydroparthenolide and two new glucosides of dihydrotamaulipin A and dihydroreynosin (1 and 2). The structures of these new compounds were determined through interpretation of their spectroscopic data including 2D-NMR spectroscopy. Syringin was also isolated from the extract. © 1990, Plenum Publishing Corporation. All rights reserved.
引用
收藏
页码：1269 / 1272
页数：4
相关论文
共 50 条
[41]   Sesquiterpene lactones with anti-inflammatory and cytotoxic activities from the roots of Cichorium intybus [J].
Meng, Xiu-hua ;
Lv, Han ;
Ding, Xiao-qin ;
Jian, Tun-yu ;
Guo, Da-le ;
Feng, Xiu-juan ;
Ren, Bing-ru ;
Chen, Jian .
PHYTOCHEMISTRY, 2022, 203
[42]   Sesquiterpene lactones enriched-fractions obtained from Cynara cardunculus extract diaultrafiltration [J].
Rosa, Daniela ;
Bras, Teresa ;
Rial, Carlos ;
Varela, Rosa M. ;
Macas, Benvindo ;
Macias, Francisco A. ;
Duarte, Maria F. .
INDUSTRIAL CROPS AND PRODUCTS, 2024, 218
[43]   New Sesquiterpene Lactone and Other Constituents from Centaurea sulphurea (Asteraceae) [J].
Lakhal, Hichem ;
Boudiar, Tarek ;
Kabouche, Ahmed ;
Kabouche, Zahia ;
Touzani, Rachid ;
Bruneau, Christian .
NATURAL PRODUCT COMMUNICATIONS, 2010, 5 (06) :849-850
[44]   In vitro antiplasmodial and cytotoxic activities of sesquiterpene lactones from Vernonia fimbrillifera Less. (Asteraceae) [J].
Bordignon, Annelise ;
Frederich, Michel ;
Ledoux, Allison ;
Campos, Pierre-Eric ;
Clerc, Patricia ;
Hermann, Thomas ;
Quetin-Leclercq, Joelle ;
Cieckiewicz, Ewa .
NATURAL PRODUCT RESEARCH, 2018, 32 (12) :1463-1466
[45]   Sesquiterpene lactones from Mikania micrantha and Mikania cordifolia and their cytotoxic and anti-inflammatory evaluation [J].
Eunice Rios, V ;
Alejandra, Leon ;
Isabel Chavez, Maria ;
Torres, Yuridia ;
Teresa Ramirez-Apan, Maria ;
Toscano, Ruben A. ;
Bravo-Monzon, Angel E. ;
Espinosa-Garcia, Francisco J. ;
Delgado, Guillermo .
FITOTERAPIA, 2014, 94 :155-163
[46]   Cajamolides A-N: Cytotoxic and anti-inflammatory sesquiterpene lactones from Calea jamaicensis [J].
Grafakou, Maria-Eleni ;
Barda, Christina ;
Karikas, George A. ;
Heilmann, Joerg ;
Skaltsa, Helen .
BIOORGANIC CHEMISTRY, 2021, 116
[47]   A new guaianolide and other sesquiterpene lactones from Centaurea acaulis L. (Asteraceae) [J].
Bentamène, A ;
Benayache, S ;
Crèche, J ;
Petit, G ;
Bermejo-Barrera, J ;
Leon, F ;
Benayache, F .
BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2005, 33 (10) :1061-1065
[48]   A flavonoid with cytotoxic activity and other constituents from Centaurea africana [J].
Seghiri, Ramdane ;
Boumaza, Ouahiba ;
Mekkiou, Ratiba ;
Benayache, Samir ;
Mosset, Paul ;
Quintana, Jose ;
Estevez, Francisco ;
Leon, Francisco ;
Bermejo, Jaime ;
Benayache, Fadila .
PHYTOCHEMISTRY LETTERS, 2009, 2 (03) :114-118
[49]   UPLC/MS/MS method for quantification and cytotoxic activity of sesquiterpene lactones isolated from Saussurea lappa [J].
Kumar, Ashish ;
Kumar, Shiv ;
Kumar, Dharmesh ;
Agnihotri, Vijai K. .
JOURNAL OF ETHNOPHARMACOLOGY, 2014, 155 (02) :1393-1397
[50]   Volsurf Descriptors to Analyse Anti-HCV and Cytotoxic Activities of Sesquiterpene Lactones from Asteraceae Family [J].
Fernandes, Mariane Ballerini ;
Rossini, Michelle ;
Stefani, Ricardo ;
Tavares, Leoberto ;
Emerenciano, Vicente de Paulo ;
Scotti, Luciana ;
da Silva, Marcelo Sobral ;
Scotti, Marcus Tullius .
LETTERS IN DRUG DESIGN & DISCOVERY, 2011, 8 (01) :44-58
12345