MURINE HERPESVIRUS 68 IS GENETICALLY RELATED TO THE GAMMAHERPESVIRUSES EPSTEIN-BARR-VIRUS AND HERPESVIRUS SAIMIRI

被引：232
作者：
EFSTATHIOU, S
HO, YM
HALL, S
STYLES, CJ
SCOTT, SD
GOMPELS, UA
机构：
[1] Division of Virology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, Tennis Court Road
来源：
JOURNAL OF GENERAL VIROLOGY | 1990年 / 71卷
关键词：
D O I：
10.1099/0022-1317-71-6-1365
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Short nucleotide sequence analysis of seven restriction fragments of murine herpesvirus 68 (MHV-68) DNA has been undertaken and used to determine the overall genome organization and relatedness of this virus to other well characterized representatives of the alpha-, beta- and gammaherpesvirus subgroups. Nine genes have been identified which encode amino acid sequences with greater similarity to proteins of the gammaherpesvirus Epstein-Barr virus (EBV) than to the homologous products of the alphaherpesviruses varicella-zoster virus and herpes simples virus type 1 or the betaherpesvirus human cytomegalovirus. In addition, the genome organization of MHV-68 is shown to have an overall collinearity with that of the gammaherpesviruses EBV and herpesvirus saimiri. In common with these viruses, dinucleotide frequency analysis of MHV-68 coding, sequences reveals a marked reduction in CpGa dinucleotide frequency thus implicating a dividing cell population as the site of latency in vivo.
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页码：1365 / 1372
页数：8
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