MURINE HERPESVIRUS 68 IS GENETICALLY RELATED TO THE GAMMAHERPESVIRUSES EPSTEIN-BARR-VIRUS AND HERPESVIRUS SAIMIRI

被引：233

作者：

EFSTATHIOU, S

HO, YM

HALL, S

STYLES, CJ

SCOTT, SD

GOMPELS, UA

机构：

[1] Division of Virology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, Tennis Court Road

来源：

JOURNAL OF GENERAL VIROLOGY | 1990年 / 71卷

关键词：

D O I：

10.1099/0022-1317-71-6-1365

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Short nucleotide sequence analysis of seven restriction fragments of murine herpesvirus 68 (MHV-68) DNA has been undertaken and used to determine the overall genome organization and relatedness of this virus to other well characterized representatives of the alpha-, beta- and gammaherpesvirus subgroups. Nine genes have been identified which encode amino acid sequences with greater similarity to proteins of the gammaherpesvirus Epstein-Barr virus (EBV) than to the homologous products of the alphaherpesviruses varicella-zoster virus and herpes simples virus type 1 or the betaherpesvirus human cytomegalovirus. In addition, the genome organization of MHV-68 is shown to have an overall collinearity with that of the gammaherpesviruses EBV and herpesvirus saimiri. In common with these viruses, dinucleotide frequency analysis of MHV-68 coding, sequences reveals a marked reduction in CpGa dinucleotide frequency thus implicating a dividing cell population as the site of latency in vivo.

引用

页码：1365 / 1372

页数：8

共 41 条

[1] DNA-SEQUENCE AND EXPRESSION OF THE B95-8 EPSTEIN-BARR VIRUS GENOME [J].

BAER, R ;

BANKIER, AT ;

BIGGIN, MD ;

DEININGER, PL ;

FARRELL, PJ ;

GIBSON, TJ ;

HATFULL, G ;

HUDSON, GS ;

SATCHWELL, SC ;

SEGUIN, C ;

TUFFNELL, PS ;

BARRELL, BG .

NATURE, 1984, 310 (5974) :207-211

[2] TERMINAL REPETITIVE SEQUENCES IN HERPESVIRUS SAIMIRI VIRION DNA [J].

BANKIER, AT ;

DIETRICH, W ;

BAER, R ;

BARRELL, BG ;

COLBEREGARAPIN, F ;

FLECKENSTEIN, B ;

BODEMER, W .

JOURNAL OF VIROLOGY, 1985, 55 (01) :133-139

[3]

BANKIER AT, 1983, TECHNIQUES NUCLEIC B, V5, P1

[4] BUFFER GRADIENT GELS AND S-35 LABEL AS AN AID TO RAPID DNA-SEQUENCE DETERMINATION [J].

BIGGIN, MD ;

GIBSON, TJ ;

HONG, GF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (13) :3963-3965

[5] DNA METHYLATION AND THE FREQUENCY OF CPG IN ANIMAL DNA [J].

BIRD, AP .

NUCLEIC ACIDS RESEARCH, 1980, 8 (07) :1499-1504

[6]

BLASKOVIC D, 1980, ACTA VIROL, V24, P468

[7] GENE SEQUENCE AND MAPPING DATA FROM MAREKS-DISEASE VIRUS AND HERPESVIRUS OF TURKEYS - IMPLICATIONS FOR HERPESVIRUS CLASSIFICATION [J].

BUCKMASTER, AE ;

SCOTT, SD ;

SANDERSON, MJ ;

BOURSNELL, MEG ;

ROSS, NLJ ;

BINNS, MM .

JOURNAL OF GENERAL VIROLOGY, 1988, 69 :2033-2042

[8] THE 160,000-MR VIRION PROTEIN ENCODED AT THE RIGHT END OF THE HERPESVIRUS SAIMIRI GENOME IS HOMOLOGOUS TO THE 140,000-MR MEMBRANE ANTIGEN ENCODED AT THE LEFT END OF THE EPSTEIN-BARR-VIRUS GENOME [J].

CAMERON, KR ;

STAMMINGER, T ;

CRAXTON, M ;

BODEMER, W ;

HONESS, RW ;

FLECKENSTEIN, B .

JOURNAL OF VIROLOGY, 1987, 61 (07) :2063-2070

[9] IDENTIFICATION OF THE MAJOR CAPSID PROTEIN GENE OF HUMAN CYTOMEGALO-VIRUS [J].

CHEE, M ;

RUDOLPH, SA ;

PLACHTER, B ;

BARRELL, B ;

JAHN, G .

JOURNAL OF VIROLOGY, 1989, 63 (03) :1345-1353

[10]

CHEE MS, 1989, IN PRESS CURRENT TOP

← 1 2 3 4 5 →