ONE-TRIAL TOLERANCE TO THE ANXIOLYTIC EFFECTS OF CHLORDIAZEPOXIDE IN THE PLUS-MAZE

被引：140

作者：

FILE, SE

机构：

[1] Psychopharmacology Research Unit, Division of Pharmacology, UMDS Guy's Hospital, London

来源：

PSYCHOPHARMACOLOGY | 1990年 / 100卷 / 02期

基金：

英国惠康基金;

关键词：

Anxiety; Benzodiazepines; Learned tolerance;

D O I：

10.1007/BF02244419

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Chlordiazepoxide (CDP 7.5 mg/kg) had a significant anxiolytic effect in rats tested on the plus-maze for the first time. On a second trial the control scores did not change, but those of the CDP group did and they no longer differed from controls. Rats previously tested undrugged or after flumazenil (4 mg/kg) also failed to show an anxiolytic response to CDP. Thus this phenomenon of one-trial tolerance depended on prior experience with the plus-maze. It also depended on CDP acting at the benzodiazepine receptors on trial 2, since the joint administration of CDP and flumazenil on trial 2 reversed the phenomenon. © 1990 Springer-Verlag.

引用

页码：281 / 282

页数：2