INVITRO METABOLISM OF PROGESTERONE, 4-ANDROSTENE-3, 17-DIONE, TESTOSTERONE AND 17-BETA-HYDROXY-5-ALPHA-ANDROSTAN-3-ONE BY FETAL RHESUS-MONKEY TESTES

被引：4

作者：

COFFEY, JC

JOHNSONBAUGH, RE

机构：

[1] UNIV N CAROLINA,SCH MED,DEPT PEDIAT,CHAPEL HILL,NC 27514

[2] UNIV N CAROLINA,SCH PUBL HLTH,DEPT PARASITOL & LAB PRACTICE,CHAPEL HILL,NC 27514

[3] NATL NAVAL MED CTR,DEPT PEDIAT,DIV ENDOCRINE,BETHESDA,MD 20014

[4] UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20014

来源：

STEROIDS | 1979年 / 33卷 / 04期

关键词：

D O I：

10.1016/0039-128X(79)90016-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Homogenates prepared from fetal rhesus monkey testes were incubated with progesterone, 4-androstene-3,17-dione, testosterone and 17β-hydroxy-5α- androstan-3-one. The major progesterone metabolite was 17-hydroxy-4-pregnene-,20-,20-dione. Testosterone also accumulated in the progesterone incubations. 4-Androstene-3,17-dione was converted chiefly to testosterone. Testosterone was not actively metabolized by the fetal monkey testis. 17β-Hydroxy-5α-androstan-3-one was actively converted primarily to 5α-androstane-3β,17β-diol. © 1979.

引用

页码：427 / 434

页数：8

共 17 条

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