Contrast enhanced ultrasound with quantitative perfusion analysis for objective characterization of pancreatic ductal adenocarcinoma: A feasibility study

被引：11
作者：
D'Onofrio, Mirko [1 ]
Canestrini, Stefano [1 ]
Crosara, Stefano [1 ]
De Robertis, Riccardo [1 ]
Mucelli, Roberto Pozzi [1 ]
机构：
[1] Univ Verona, Univ Hosp GB Rossi, Dept Radiol, Piazzale LA Scuro 10, I-37134 Verona, Italy
来源：
WORLD JOURNAL OF RADIOLOGY | 2014年 / 6卷 / 03期
关键词：
Contrast enhanced ultrasound; Pancreatic adenocarcinoma; Perfusion analysis; Quantitative imaging;
D O I：
10.4329/wjr.v6.i3.31
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The aim of this study was to determine whether contrast enhanced ultrasound (CEUS) quantitative perfusion analysis allows an objective characterization of ductal adenocarcinoma (ADK) of the pancreas. Patients with pancreatic ADK underwent CEUS. All examinations were performed on an Acuson S2000 system (Siemens, Erlangen, Germany) after the iv administration of 2.4 mL contrast agent (SonoVue (R), Bracco, Milan, Italy). All lesions were pathologically proved. An operator manually drew different regions of interest within the tumor and the adjacent parenchyma to allow the quantitative perfusion analysis. The mean values of peak of enhancement, time to peak and ascending curve were calculated and compared using the Student's t test. The quantitative perfusion analysis was possible in all lesions. The mean values of the peak of enhancement, time to peak and ascending curve were 17.19%, 7.97 s and 159.52% s within the tumor and 33.57%, 8.89 s and 355.29% s within the adjacent parenchyma. The peak of enhancement and the ascending curve values were significantly different within the tumor and the adjacent parenchyma. Thus, CEUS allows the quantitative perfusion analysis of pancreatic ductal adenocarcinoma. (c) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.
引用
收藏
页码：31 / 35
页数：5
相关论文
共 23 条
[1]   Pancreatic perfusion:: Noninvasive quantitative assessment with dynamic contrast-enhanced MR imaging without and with secretin stimulation in healthy volunteers -: Initial results [J].
Bali, Maria Antonietta ;
Metens, Thierry ;
Denolin, Vincent ;
De Maertelaer, Viviane ;
Deviere, Jacques ;
Matos, Celso .
RADIOLOGY, 2008, 247 (01) :115-121
[2]   Resectable Pancreatic Cancer: Who Really Benefits From Resection? [J].
Barugola, Giuliano ;
Partelli, Stefano ;
Marcucci, Stefano ;
Sartori, Nora ;
Capelli, Paola ;
Bassi, Claudio ;
Pederzoli, Paolo ;
Falconi, Massimo .
ANNALS OF SURGICAL ONCOLOGY, 2009, 16 (12) :3316-3322
[3]   Pancreatic Endocrine Tumors: Tumor Blood Flow Assessed with Perfusion CT Reflects Angiogenesis and Correlates with Prognostic Factors [J].
d'Assignies, Gaspard ;
Couvelard, Anne ;
Bahrami, Stephane ;
Vullierme, Marie-Pierre ;
Hammel, Pascal ;
Hentic, Olivia ;
Sauvanet, Alain ;
Bedossa, Pierre ;
Ruszniewski, Philippe ;
Vilgrain, Valerie .
RADIOLOGY, 2009, 250 (02) :407-416
[4]   Ultrasonography of the pancreas. 4. Contrast-enhanced imaging [J].
D'Onofrio, M. ;
Zamboni, G. ;
Faccioli, N. ;
Capelli, P. ;
Pozzi Mucelli, R. .
ABDOMINAL IMAGING, 2007, 32 (02) :171-181
[5]   Contrast-enhanced ultrasonography better identifies pancreatic tumor vascularization than helical CT [J].
D'Onofrio, M ;
Malagò, R ;
Zamboni, G ;
Vasori, S ;
Falconi, M ;
Capelli, P ;
Manuseto, G .
PANCREATOLOGY, 2005, 5 (4-5) :398-402
[6]   RESECTABLE PANCREATIC ADENOCARCINOMA: IS THE ENHANCEMENT PATTERN AT CONTRAST-ENHANCED ULTRASONOGRAPHY A PRE-OPERATIVE PROGNOSTIC FACTOR? [J].
D'Onofrio, M. ;
Zamboni, G. A. ;
Malago, R. ;
Mantovani, W. ;
Principe, F. ;
Gallotti, A. ;
Faccioli, N. ;
Falconi, M. ;
Capelli, P. ;
Mucelli, R. Pozzi .
ULTRASOUND IN MEDICINE AND BIOLOGY, 2009, 35 (12) :1929-1937
[7]  
D'Onofrio M, 2007, J PANCREAS, V8, P71
[8]   Imaging techniques in pancreatic tumors [J].
D'Onofrio, Mirko ;
Gallotti, Anna ;
Mucelli, Roberto Pozzi .
EXPERT REVIEW OF MEDICAL DEVICES, 2010, 7 (02) :257-273
[9]  
Dietrich CF, 2008, J CANCER RES CLIN, V134, P635, DOI 10.1007/s00432-007-0326-6
[10]   Quantitative Perfusion Analysis of Transabdominal Contrast-Enhanced Ultrasonography of Pancreatic Masses and Carcinomas [J].
Kersting, Stephan ;
Konopke, Ralf ;
Kersting, Florina ;
Volk, Andreas ;
Distler, Marius ;
Bergert, Hendrik ;
Saeger, Hans-Detlev ;
Gruetzmann, Robert ;
Bunk, Alfred .
GASTROENTEROLOGY, 2009, 137 (06) :1903-1911
123