Investigation That the Serum Neopterin Levels in Nonreplicative HBV Carriers, the Patients Infected Chronic HBV and Natural Immunized Persons

Aim: Neopterin is a pyrazino-pyrimidine compound, which originate, from guanosine triphosphate. Its derivatives are produced by human monocyte, macrophages and dendritic cells upon stimulations with interferon-a. Measurement of neopterin concentrations in human body fluids allows insight into a specific aspect of immunity, namely, the cell mediated immune response. The aim of this study was to investigate the levels of neopterin in patients infected hepatitis B. Material and Methods: In this study, we investigated of serum neopterin levels in nonreplicative HBV carriers, patients with chronic HBV infection and naturel immunized persons against to HBV. 20 patients with nonreplicative HBV carriers (group 1), 20 patients with chronic HBV infections (group 2), 20 persons with natural immunized against to HBV (group 3)' and 20 healthy persons (group 4) ' had included to study. Results: Serum neopterin levels were 7,44 +/- 3,44 nmol/l in group 1, 18,58 +/- 12,19 nmol/l in group 2, 7,51 +/- 10,18 nmol/l in group 3, 5,71 +/- 2,92 nmol/l in group 4. The difference between group 1 and group 4, group 3 and group 4 was not statistically significant (p>0.05). The difference among between group 2 and the other groups was statistically significant (p<0.05). Conclusion: In, conclusion; neopterin can be used as marker in nonreplicative HBV carriers and patients with chronic HBV infection. But we believe that further studies with large series are needed to using routine.