RADIOLABELING OF POLYMER MICROSPHERES FOR SCINTIGRAPHIC INVESTIGATIONS BY NEUTRON-ACTIVATION .1. INCORPORATION OF SAMARIUM OXIDE AND ITS EFFECTS ON THE PROPERTIES OF EUDRAGIT RS - SULFASALAZINE MICROSPHERES

被引：11

作者：

WATTS, PJ

ATKIN, BP

WILSON, CG

DAVIES, MC

MELIA, CD

机构：

[1] UNIV NOTTINGHAM,DEPT PHARMACEUT SCI,NOTTINGHAM NG7 2RD,ENGLAND

[2] UNIV NOTTINGHAM,DEPT PHYSIOL & PHARMACOL,NOTTINGHAM NG7 2RD,ENGLAND

[3] UNIV NOTTINGHAM,DEPT MIN ENGN,NOTTINGHAM NG7 2RD,ENGLAND

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 76卷 / 1-2期

关键词：

EUDRAGIT RS MICROSPHERE; SOLVENT EVAPORATION; GAMMA-SCINTIGRAPHY; NEUTRON ACTIVATION; SAMARIUM OXIDE;

D O I：

10.1016/0378-5173(91)90343-M

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Eudragit RS: sulphasalazine microspheres containing 0-0.8% w/w samarium oxide (Sm2O3) have been produced using a conventional emulsification-solvent evaporation technique. Direct quantification of incorporated Sm2O3 was achieved using X-ray fluorescence spectroscopy (XRF). The efficiency of Sm3O3 incorporation increased with concentration but microsphere yield, appearance, drug content and drug release rate were unaffected by Sm2O3 content over the concentration range investigated. Incorporation of Sm2O3 by solvent evaporation would appear to offer a convenient method for producing microspheres to be radiolabelled by neutron activation for use in scintigraphic studies.

引用

页码：55 / 59

页数：5

共 8 条

[1]

HARDY JG, 1991, ALIMENT PHARM THERAP, V5, P69

[2] RADIOLABELING OF INTACT DOSAGE FORMS BY NEUTRON-ACTIVATION - EFFECTS ON INVITRO PERFORMANCE [J].