THE G-PROTEIN CONNECTION - MOLECULAR-BASIS OF MEMBRANE ASSOCIATION

被引：114

作者：

SPIEGEL, AM ^{[1
]}

BUTRYNSKI, JE ^{[1
]}

JONES, TLZ ^{[1
]}

SIMONDS, WF ^{[1
]}

BACKLUND, PS ^{[1
]}

机构：

[1] NIMH,GEN & COMPARAT BIOCHEM LAB,BETHESDA,MD 20892

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1991年 / 16卷 / 09期

关键词：

D O I：

10.1016/0968-0004(91)90139-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two distinct types of lipid modification, myristoylation and isoprenylation, are critical for membrane association of heterotrimeric G proteins. Elucidation of the molecular basis for G protein membrane association has important implications for understanding G protein structure and function, and is relevant to potential therapeutic approaches to AIDS and cancer.

引用

收藏

页码：338 / 341

页数：4

相关论文

共 50 条

[11] Molecular basis for the evolved instability of a human G-protein coupled receptor [J].

Chamness, Laura M. ;

Zelt, Nathan B. ;

Harrington, Haley R. ;

Kuntz, Charles P. ;

Bender, Brian J. ;

Penn, Wesley D. ;

Ziarek, Joshua J. ;

Meiler, Jens ;

Schlebach, Jonathan P. .

CELL REPORTS, 2021, 37 (08)

[12] MOLECULAR BASIS FOR THE EVOLVED INSTABILITY OF A HUMAN G-PROTEIN COUPLED RECEPTOR [J].

Chamness, Laura ;

Kuntz, Charles ;

Penn, Wesley ;

Meiler, Jens ;

Schlebach, Jonathan .

PROTEIN SCIENCE, 2019, 28 :79-79

[13] THE MOLECULAR-BASIS OF HLA-DISEASE ASSOCIATION [J].

BELL, JI ;

TODD, JA ;

MCDEVITT, HO .

ADVANCES IN HUMAN GENETICS, 1989, 18 :1-41

[14] MOLECULAR-BASIS OF BACTERIAL OUTER-MEMBRANE PERMEABILITY [J].

NIKAIDO, H ;

VAARA, M .

MICROBIOLOGICAL REVIEWS, 1985, 49 (01) :1-32

[15] THE MOLECULAR-BASIS OF INCREASED RIGIDITY OF THE ERYTHROCYTE-MEMBRANE [J].

PESCARMONA, GP ;

GHIGO, D ;

BOSIA, A .

RICERCA IN CLINICA E IN LABORATORIO, 1983, 13 :141-147

[16] MEMBRANE ORGANIZATION IN G-PROTEIN MECHANISMS [J].

NEUBIG, RR .

FASEB JOURNAL, 1994, 8 (12) :939-946

[17] ANTIBODIES AS PROBES OF G-PROTEIN RECEPTOR EFFECTOR COUPLING AND OF G-PROTEIN MEMBRANE ATTACHMENT [J].

SPIEGEL, AM ;

SIMONDS, WF ;

JONES, TLZ ;

GOLDSMITH, PK ;

UNSON, CG .

BIOCHEMICAL SOCIETY SYMPOSIA, 1990, (56) :61-69

[18] MOLECULAR-BASIS OF MEMBRANE RIGIDITY IN SOUTHEAST-ASIAN OVALOCYTOSIS - OLIGOMERIZATION OF THE MUTANT BAND-3 PROTEIN AND ITS INCREASED ASSOCIATION WITH THE MEMBRANE SKELETON [J].

LIU, SC ;

NICHOLS, PE ;

YI, SJ ;

DERICK, LH ;

CHIOU, SS ;

AMATO, D ;

PALEK, J .

BLOOD, 1993, 82 (10) :A308-A308

[19] MOLECULAR-BASIS FOR RED-CELL MEMBRANE VISCOELASTIC PROPERTIES [J].

MOHANDAS, N .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1992, 20 (04) :776-782

[20] MOLECULAR MECHANISMS OF G-PROTEIN ACTIVATION [J].

JAKOBS, KH ;

GIERSCHIK, P ;

HILF, G ;

REITHMANN, C ;

SIDIROPOULOS, D ;

WIELAND, T .

BIOLOGICAL CHEMISTRY HOPPE-SEYLER, 1989, 370 (04) :278-278

← 1 2 3 4 5 →