THE G-PROTEIN CONNECTION - MOLECULAR-BASIS OF MEMBRANE ASSOCIATION

被引：114

作者：

SPIEGEL, AM ^{[1
]}

BUTRYNSKI, JE ^{[1
]}

JONES, TLZ ^{[1
]}

SIMONDS, WF ^{[1
]}

BACKLUND, PS ^{[1
]}

机构：

[1] NIMH,GEN & COMPARAT BIOCHEM LAB,BETHESDA,MD 20892

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1991年 / 16卷 / 09期

关键词：

D O I：

10.1016/0968-0004(91)90139-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two distinct types of lipid modification, myristoylation and isoprenylation, are critical for membrane association of heterotrimeric G proteins. Elucidation of the molecular basis for G protein membrane association has important implications for understanding G protein structure and function, and is relevant to potential therapeutic approaches to AIDS and cancer.

引用

页码：338 / 341

页数：4

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