OXYGEN FREE-RADICALS AND BRAIN-DYSFUNCTION

被引:212
作者
JESBERGER, JA
RICHARDSON, JS
机构
[1] UNIV SASKATCHEWAN, COLL MED, DEPT PHARMACOL, SASKATOON S7N 0W0, SASKATCHEWAN, CANADA
[2] UNIV SASKATCHEWAN, COLL MED, DEPT PSYCHIAT, SASKATOON S7N 0W0, SASKATCHEWAN, CANADA
关键词
OXYGEN FREE RADICALS; NEURONAL DEGENERATION; CEREBRAL ISCHEMIA; SEIZURE DISORDERS; SCHIZOPHRENIA; TARDIVE DYSKINESIA; AGING; PARKINSONS DISEASE; ALZHEIMERS DISEASE;
D O I
10.3109/00207459109150342
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Oxygen free radicals, any chemical moiety containing an oxygen atom with an unpaired electron in the outer orbital shell, are generated during many normal biochemical reactions in living tissue. The unpaired electron makes these compounds highly reactive and they can initiate disruptive peroxidation reactions with various substrates important to the survival of cells such as proteins, lipids and nucleic acids. A fairly complex defense system has evolved to protect living tissue from free radicals and to minimize the damage they might cause. Neurons are especially vulnerable to free radical attack and impaired defenses or exposure to excess free radicals can lead to neuronal death. Free radicals contribute to neuronal loss in cerebral ischemia and hemorrhage and may be involved in the degeneration of neurons in epilepsy, schizophrenia, tardive dyskinesia, normal aging, Parkinson's Disease and Alzheimer's Disease. The development of drugs that limit or prevent the attack of free radicals on neurons would be an important advance in the treatment of these conditions. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码:1 / 17
页数:17
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