PENICILLIN PRODUCTION IN AN INVERSE FLUIDIZED-BED BIOREACTOR

被引：10

作者：

RAMSAY, BA ^{[1
]}

WANG, DG ^{[1
]}

CHAVARIE, C ^{[1
]}

ROULEAU, D ^{[1
]}

RAMSAY, JA ^{[1
]}

机构：

[1] ECOLE POLYTECH,DEPT GENIE CHIM,CP 6079,SUCCURSALE A,MONTREAL H3C 3A7,QUEBEC,CANADA

来源：

JOURNAL OF FERMENTATION AND BIOENGINEERING | 1991年 / 72卷 / 06期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/0922-338X(91)90064-N

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The inverse fluidized bed bioreactor was adapted for the axenic culture of heterotrophic microorganisms. Penicillin V synthesized by Penicillium chrysogenum ATCC 28089 was used as a model system for secondary metabolite production. The biomass growth rate was controlled by the rate of nutrient addition while an eroder in the inner draft tube limited the maximum biofilm thickness. When a lactose-rich, mineral salts medium was added at a rate of 0.024 l.h-1, the maximum specific productivity was 5.79 x 10(-4) g (Pen V).g (biomass)-1.h-1.

引用

页码：495 / 497

页数：3

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