E-10-HYDROXYLATION AND Z-10-HYDROXYLATION OF NORTRIPTYLINE - RELATIONSHIP TO POLYMORPHIC DEBRISOQUINE HYDROXYLATION

被引:224
作者
MELLSTROM, B
BERTILSSON, L
SAWE, J
SCHULZ, HU
SJOQVIST, F
机构
[1] KAROLINSKA INST,HUDDINGE HOSP,DEPT CLIN PHARMACOL,HUDDINGE,SWEDEN
[2] MED SCH LUBECK,DEPT ANGIOL & GERIAT,LUBECK,FED REP GER
关键词
D O I
10.1038/clpt.1981.147
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:189 / 193
页数:5
相关论文
共 20 条
[2]   STEADY-STATE PLASMA LEVELS OF NORTRIPTYLINE INTWINS - INFLUENCE OF GENETIC FACTORS AND DRUG THERAPY [J].
ALEXANDERSON, B ;
EVANS, DAP ;
SJOQVIST, F .
BMJ-BRITISH MEDICAL JOURNAL, 1969, 4 (5686) :764-+
[3]   URINARY-EXCRETION OF NORTRIPTYLINE AND 5 OF ITS METABOLITES IN MAN AFTER SINGLE AND MULTIPLE ORAL DOSES [J].
ALEXANDERSON, B ;
BORGA, O .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1973, 5 (03) :174-180
[4]   PREDICTION OF STEADY-STATE PLASMA LEVELS OF NORTRIPTYLINE FROM SINGLE ORAL DOSE KINETICS - STUDY IN TWINS [J].
ALEXANDERSON, B .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1973, 6 (01) :44-53
[5]   GENETIC CONROL OF NORTIPTYLINE KINETICS IN MAN - STUDY OF RELATIVES OF PROPOSITI WITH HIGH PLASMA CONCENTRATIONS [J].
ASBERG, M ;
EVANS, DAP ;
SJOQVIST, F .
JOURNAL OF MEDICAL GENETICS, 1971, 8 (02) :129-&
[6]   PRONOUNCED INHIBITION OF NORADRENALINE UPTAKE BY 10-HYDROXY-METABOLITES OF NORTRIPTYLINE [J].
BERTILSSON, L ;
MELLSTROM, B ;
SJOQVIST, F .
LIFE SCIENCES, 1979, 25 (15) :1285-1292
[7]   PHARMACOGENETIC COVARIATION OF DEFECTIVE N-OXIDATION OF SPARTEINE AND 4-HYDROXYLATION OF DEBRISOQUINE [J].
BERTILSSON, L ;
DENGLER, HJ ;
EICHELBAUM, M ;
SCHULZ, HU .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1980, 17 (02) :153-155
[8]   NORTRIPTYLINE AND ANTIPYRINE CLEARANCE IN RELATION TO DEBRISOQUINE HYDROXYLATION IN MAN [J].
BERTILSSON, L ;
EICHELBAUM, M ;
MELLSTROM, B ;
SAWE, J ;
SCHULZ, HU ;
SJOQVIST, F .
LIFE SCIENCES, 1980, 27 (18) :1673-1677
[9]   STEREOSPECIFIC HYDROXYLATION OF NORTRIPTYLINE IN MAN IN RELATION TO INTERINDIVIDUAL DIFFERENCES IN ITS STEADY-STATE PLASMA LEVEL [J].
BERTILSSON, L ;
ALEXANDERSON, B .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1972, 4 (04) :201-+
[10]  
BORGA O, 1972, 5TH P INT C PHARM, V3, P56