PERIPHERALLY ADMINISTERED SUBSTANCE-P AFFECTS EXTRACELLULAR DOPAMINE CONCENTRATIONS IN THE NEOSTRIATUM BUT NOT IN THE NUCLEUS-ACCUMBENS UNDER ANESTHESIA

被引：13
作者：
BOIX, F
MATTIOLI, R
ADAMS, F
HUSTON, JP
SCHWARTING, RKW
机构：
[1] Institute of Physiological Psychology I, University of Düsseldorf, 4000 Düsseldorf 1, Universitätsstr. l
来源：
BRAIN RESEARCH BULLETIN | 1993年 / 31卷 / 06期
关键词：
NEUROKININS; DOPAMINE; NEOSTRIATUM; NUCLEUS ACCUMBENS; URETHANE; INSITU MICRODIALYSIS; ANESTHESIA;
D O I：
10.1016/0361-9230(93)90137-Z
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The in situ microdialysis technique was used in urethane-anesthetized rats to monitor changes in the extracellular concentrations of dopamine and its metabolites in neostriatum and nucleus accumbens after the peripheral administration of substance P (50 or 250 mug/kg, IP). Four to five hours after urethane anesthesia a decrease of extracellular dopamine and its metabolites was observed which continued in the nucleus accumbens in the following 3 h. The administration of substance P induced a decrease in extracellular concentration of dopamine in neostriatum. This neurochemical change after substance P was not accompanied by parallel alterations in extracellular concentrations of dopamine metabolites. No effects of substance P were observed on dopamine or its metabolites in nucleus accumbens. These data are discussed in relation with the contrasting effects of substance P on awake rats and the possible changes in striatal dopamine activity induced by anesthetics.
引用
收藏
页码：655 / 660
页数：6
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