DETERMINATION OF ETOPOSIDE IN BLOOD BY LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION

被引：11
|
作者：
EISENBERG, EJ [1 ]
EICKHOFF, WM [1 ]
机构：
[1] STERLING WINTHROP INC,DEPT PHARMACEUT SCI,MALVERN,PA 19355
来源：
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 621卷 / 01期
关键词：
D O I：
10.1016/0378-4347(93)80084-H
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A liquid chromatographic (LC) method for determination of etoposide in dog blood is described. The technique includes solvent extraction of etoposide using a dichloroethane-hexane mixture and reconstitution of the drug in an aqueous reconstitution solution. The samples are analyzed by reversed-phase LC with electrochemical detection. Validation of the method demonstrated good sensitivity, precision and reproducibility. The method is useful for the study of etoposide pharmacokinetics in the dog.
引用
收藏
页码：110 / 114
页数：5
相关论文
共 50 条
  • [31] INDIRECT ELECTROCHEMICAL DETECTION IN LIQUID-CHROMATOGRAPHY
    YE, JN
    BALDWIN, RP
    RAVICHANDRAN, K
    ANALYTICAL CHEMISTRY, 1986, 58 (11) : 2337 - 2340
  • [32] ELECTROCHEMICAL DETECTION OF IONS IN LIQUID-CHROMATOGRAPHY
    OSTROVIDOV, EA
    KULESHOVA, LA
    MITINA, SI
    VINOGRADOVA, RG
    VORONTSOV, AM
    KANEV, AS
    RYSEV, OA
    JOURNAL OF ANALYTICAL CHEMISTRY OF THE USSR, 1980, 35 (09): : 1089 - 1092
  • [33] MICELLAR LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION
    KHALEDI, MG
    DORSEY, JG
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1984, 187 (APR): : 84 - ANYL
  • [34] LIQUID-CHROMATOGRAPHY AND ELECTROCHEMICAL DETECTION OF PEPTIDES
    SAUTER, A
    PHARMACEUTISCH WEEKBLAD-SCIENTIFIC EDITION, 1988, 10 (01) : 32 - 33
  • [35] DETERMINATION OF HIGENAMINE IN PLASMA AND URINE BY HIGHPERFORMANCE LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION
    LO, CF
    CHEN, CM
    JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1994, 655 (01): : 33 - 39
  • [36] DETERMINATION OF GAMMA-AMINOBUTYRIC ACID BY LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION
    CAUDILL, WL
    HOUCK, GP
    WIGHTMAN, RM
    JOURNAL OF CHROMATOGRAPHY, 1982, 227 (02): : 331 - 339
  • [37] DETERMINATION OF CARBARYL BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION
    KAWAI, S
    GOTO, K
    KANO, K
    KUBOTA, T
    JOURNAL OF CHROMATOGRAPHY, 1988, 442 : 451 - 454
  • [38] DETERMINATION OF XANTHOMEGNIN IN GRAINS AND ANIMAL FEEDS BY LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION
    CARMAN, AS
    KUAN, SS
    FRANCIS, OJ
    WARE, GM
    LUEDTKE, AE
    JOURNAL OF THE ASSOCIATION OF OFFICIAL ANALYTICAL CHEMISTS, 1984, 67 (06): : 1095 - 1098
  • [39] DETERMINATION OF SERUM-CHOLINESTERASE ACTIVITY BY LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION
    MILLER, RB
    BLANK, CL
    ANALYTICAL BIOCHEMISTRY, 1991, 196 (02) : 377 - 384
  • [40] DETERMINATION OF CEPHALOSPORINS AND DECOMPOSITION PRODUCTS BY LIQUID-CHROMATOGRAPHY WITH INDIRECT ELECTROCHEMICAL DETECTION
    FABRE, H
    KOK, WT
    ANALYTICAL CHEMISTRY, 1988, 60 (02) : 136 - 141
12345