Transcutaneous Electrical Retinal Stimulation Therapy for Age-Related Macular Degeneration

被引：31

作者：

Shinoda, Kei ^{[1
,2
]}

Imamura, Yutaka ^{[1
]}

Matsuda, Sayaka ^{[1
]}

Seki, Maiko ^{[1
]}

Uchida, Atsuro ^{[1
]}

Grossman, Terry ^{[3
]}

Tsubota, Kazuo ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Ophthalmol, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan

[2] Natl Hosp Org, Tokyo Medi Ctr, Natl Inst Sensory Organs, Lab Visual Physiol,Meguro Ku, Tokyo 1528902, Japan

[3] Frontier Med Inst, Golden, CO 80401 USA

来源：

OPEN OPHTHALMOLOGY JOURNAL | 2008年 / 2卷

关键词：

D O I：

10.2174/1874364100802010132

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

This reports the preliminary outcome of a transpalpebral electrical retinal stimulation therapy for age-related macular degeneration (ARMD). Twenty-one patients consisting of 16 with wet-type (Group-W) and 5 with dry-type (Group-D) ARMD with a mean age of 73.9 +/- 9.5 years (range 51 to 85 years) were recruited for this study. Transpalpebral electrical retinal stimulation (20 minutes, 800 mu A) was applied on the patients 4 times per day for up to 1 month. The mean best-corrected visual acuity (Early Treatment Diabetic Retinopathy Study [ETDRS] score) changed from 29.5 +/- 5.1 to 31.8 +/- 5.0 in Group-W and from 39.8 +/- 4.7 to 42.9 +/- 4.9 in Group-D. Neither ocular nor systemic adverse effects were observed with the exception of one patient who developed contact dermatitis. Due to several limitations such as lack of control, patients' learning effect, etc, the efficacy of the therapy could not be drawn. This preliminary study, however, showed that the transpalpebral electrical retinal stimulation therapy can be non-invasively applied on wet-type ARMD patients.

引用

页码：132 / 136

页数：5

共 33 条

[1] Electrical stimulation accelerates and increases expression of BDNF and trkB rnRNA in regenerating rat femoral motoneurons [J].

Al-Majed, AA ;

Brushart, TM ;

Gordon, T .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 (12) :4381-4390

[2]

Arnold J, 2001, AM J OPHTHALMOL, V131, P541

[3]

Bessler NM, 2004, RETINA, V24, P990

[4]

Bhavsar A, 2004, RETINA-J RET VIT DIS, V24, P512

[5]

Bressler NM, 2000, ARCH OPHTHALMOL-CHIC, V118, P488

[6]

Bressler NM, 1999, ARCH OPHTHALMOL-CHIC, V117, P1329

[7] The artificial silicon retina microchip for the treatment of vision loss from retinitis pigmentosa [J].

Chow, AY ;

Chow, VY ;

Packo, KH ;

Pollack, JS ;

Peyman, GA ;

Schuchard, R .

ARCHIVES OF OPHTHALMOLOGY, 2004, 122 (04) :460-469

[8]

Clemons TE, 2004, ARCH OPHTHALMOL-CHIC, V122, P716

[9] Complement factor H polymorphism and age-related macular degeneration [J].

Edwards, AO ;

Ritter, R ;

Abel, KJ ;

Manning, A ;

Panhuysen, C ;

Farrer, LA .

SCIENCE, 2005, 308 (5720) :421-424

[10] Ranibizumab in neovascular age-related macular degeneration [J].

Eng, Kenneth T. ;

Kertes, Peter J. .

CLINICAL INTERVENTIONS IN AGING, 2006, 1 (04) :451-466

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