ADDITIONS OF ALDEHYDES TO METALLATED TRANS-1,3-DITHIANE-S,S-DIOXIDE UNDER CONDITIONS OF KINETIC AND THERMODYNAMIC CONTROL

被引：19

作者：

AGGARWAL, VK ^{[1
]}

DAVIES, IW ^{[1
]}

MADDOCK, J ^{[1
]}

MAHON, MF ^{[1
]}

MOLLOY, KC ^{[1
]}

机构：

[1] UNIV BATH,XRAY CRYSTALLOG UNIT,BATH BA2 7AY,AVON,ENGLAND

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 01期

关键词：

D O I：

10.1016/S0040-4039(00)94354-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The chiral acyl anion equivalent (1) can be metallated with n-BuLi/py and reacts with aldehydes to give adducts in high yield. At -78δC the reaction is under kinetic control whereas at 0δC equilibration occurs with PhCHO and t-BuCHO resulting in good yields of single diastereoisomers. © 1990.

引用

页码：135 / 138

页数：4

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