INFLUENCE OF THIOCOMPOUNDS ON THE METABOLISM OF N-NITROSODIETHYLAMINE

被引：9
作者：
FRANK, N [1 ]
BERTRAM, B [1 ]
FREI, E [1 ]
HADJIOLOV, D [1 ]
WIESSLER, M [1 ]
机构：
[1] CTR ONCOL, SOFIA DARVENITZA, BULGARIA
来源：
CARCINOGENESIS | 1988年 / 9卷 / 07期
关键词：
D O I：
10.1093/carcin/9.7.1303
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Diethyldithiocarbaminate (DDTC), mercaptoethanesulfonate (MESNA) and ethylxanthate (PEX) were tested for their influence on N-nitrosodiethylamine (NDEA) metabolism. The exhalation rate of 14CO2 released from [14C]NDEA was decreased by PEX, but not by MESNA or DDTC. The sulfur compounds led to an increased excretion of unchanged NDEA in urine in the order PEX > DDTC > > MESNA. The activity of NDEA-deethylase in liver microsomal system was decreased only after DDTC or PEX treatment. Glutathione content and glutathione-S-transferase activity were not affected significantly by any of the tested compounds. NDEA-induced single-strand breaks in liver cell DNA were inhibited after PEX treatment.
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页码：1303 / 1306
页数：4
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