THE SEPARATED ENANTIOMERS OF 2'-DEOXY-3'-THIACYTIDINE (BCH-189) BOTH INHIBIT HUMAN-IMMUNODEFICIENCY-VIRUS REPLICATION INVITRO

被引：296

作者：

COATES, JAV

CAMMACK, N

JENKINSON, HJ

MUTTON, IM

PEARSON, BA

STORER, R

CAMERON, JM

PENN, CR

机构：

[1] GLAXO GRP RES LTD,DEPT VIROL,GREENFORD RD,GREENFORD UB6 0HE,MIDDX,ENGLAND

[2] GLAXO GRP RES LTD,DEPT STRUCT CHEM,GREENFORD UB6 0HE,MIDDX,ENGLAND

[3] GLAXO GRP RES LTD,DEPT MED CHEM,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 01期

关键词：

D O I：

10.1128/AAC.36.1.202

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-enantiomer (3TC) is considerably less cytotoxic than the (+)-enantiomer.

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页码：202 / 205

页数：4

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