SPONTANEOUS OROFACIAL DYSKINESIAS IN A CAPTIVE CYNOMOLGUS MONKEY - IMPLICATIONS FOR TARDIVE-DYSKINESIA

被引：6

作者：

RUPNIAK, NMJ

TYE, SJ

STEVENTON, MJ

BOYCE, S

IVERSEN, SD

机构：

[1] Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, Terlings Park

来源：

MOVEMENT DISORDERS | 1990年 / 5卷 / 04期

关键词：

Acetylcholine; Dopamine; Dyskinesia; Institutionalization; Primates;

D O I：

10.1002/mds.870050410

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We describe a syndrome of spontaneous orofacial dyskinesias and cage stereotypies in a singly housed adult cynomolgus monkey never previously exposed to neuroleptic drugs. Abnormal movements were readily suppressed by acute treatment with haloperidol (0.03–0.24 mg/kg i.m.) or SCH23390 (0.05–0.2 mg/kg i.m.) but not by physostigmine (0.005–0.04 mg/kg i.m.) or scopolamine (0.0025–0.04 mg/kg i.m.). The symptomatology and response to pharmacological manipulations was indistinguishable from that previously attributed to chronic neuroleptic treatment in primates. Our findings indicate that neuroleptic‐induced tardive dyskinesias in most primate studies have not been clearly demonstrated. Copyright © 1990 Movement Disorder Society

引用

页码：314 / 318

页数：5

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