SPECIFIC BINDING OF CALCIUM-DEPENDENT REGULATOR PROTEIN TO BRAIN MEMBRANES FROM GUINEA-PIG

被引：35
作者：
VANDERMEERS, A
ROBBERECHT, P
VANDERMEERSPIRET, MC
RATHE, J
CHRISTOPHE, J
机构：
[1] Department of Biochemistry, Université libre de Bruxelles, School of Medicine, B-1000 Brussels
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1978年 / 84卷 / 04期
关键词：
D O I：
10.1016/0006-291X(78)91693-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The interaction of a calcium-dependent regulator protein (CDR) of brain adenylate cyclase (EC 4.6.1.1) with synaptic membranes from guinea pig brain was examined using 125I-CDR as a tracer molecule. 125I-CDR binding was reversible, saturable, and temperature sensitive. The same Ca2+ and Mg2+ dependence was observed for 125I-CDR binding and for brain adenylate cyclase activation by CDR. © 1978.
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页码：1076 / 1081
页数：6
相关论文
共 22 条
[1]  
BROSTROM CO, 1977, J BIOL CHEM, V252, P5677
[2]   IDENTIFICATION OF A CALCIUM-BINDING PROTEIN AS A CALCIUM-DEPENDENT REGULATOR OF BRAIN ADENYLATE CYCLASE [J].
BROSTROM, CO ;
HUANG, YC ;
BRECKENRIDGE, BM ;
WOLFF, DJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (01) :64-68
[3]   PROTEIN ACTIVATOR OF CYCLIC 3'-5'-NUCLEOTIDE PHOSPHODIESTERASE OF BOVINE OR RAT-BRAIN ALSO ACTIVATES ITS ADENYLATE CYCLASE [J].
CHEUNG, WY ;
BRADHAM, LS ;
LYNCH, TJ ;
LIN, YM ;
TALLANT, EA .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1975, 66 (03) :1055-1062
[4]   CYCLIC 3,5-NUCLEOTIDE PHOSPHODIESTERASE . DEMONSTRATION OF AN ACTIVATOR [J].
CHEUNG, WY .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1970, 38 (03) :533-&
[5]  
DEDMAN JR, 1977, J BIOL CHEM, V252, P8415
[6]   CHARACTERIZATION OF VIP-SENSITIVE ADENYLATE-CYCLASE IN GUINEA-PIG BRAIN [J].
DESCHODTLANCKMAN, M ;
ROBBERECHT, P ;
CHRISTOPHE, J .
FEBS LETTERS, 1977, 83 (01) :76-80
[7]   RELEASE OF PHOSPHODIESTERASE ACTIVATOR BY CYCLIC AMP-DEPENDENT ATP - PROTEIN PHOSPHOTRANSFERASE FROM SUBCELLULAR-FRACTIONS OF RAT-BRAIN [J].
GNEGY, ME ;
NATHANSON, JA ;
UZUNOV, P .
BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 497 (01) :75-85
[8]   CONFORMATIONAL TRANSITION ACCOMPANYING BINDING OF CA-2+ TO PROTEIN ACTIVATOR OF 3',5'-CYCLIC ADENOSINE-MONOPHOSPHATE PHOSPHODIESTERASE [J].
KLEE, CB .
BIOCHEMISTRY, 1977, 16 (05) :1017-1024
[9]  
LIN YM, 1974, J BIOL CHEM, V249, P4943
[10]  
LIU YP, 1976, J BIOL CHEM, V251, P4193
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