SPECIFIC BINDING OF CALCIUM-DEPENDENT REGULATOR PROTEIN TO BRAIN MEMBRANES FROM GUINEA-PIG

被引：35
作者：
VANDERMEERS, A
ROBBERECHT, P
VANDERMEERSPIRET, MC
RATHE, J
CHRISTOPHE, J
机构：
[1] Department of Biochemistry, Université libre de Bruxelles, School of Medicine, B-1000 Brussels
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1978年 / 84卷 / 04期
关键词：
D O I：
10.1016/0006-291X(78)91693-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The interaction of a calcium-dependent regulator protein (CDR) of brain adenylate cyclase (EC 4.6.1.1) with synaptic membranes from guinea pig brain was examined using 125I-CDR as a tracer molecule. 125I-CDR binding was reversible, saturable, and temperature sensitive. The same Ca2+ and Mg2+ dependence was observed for 125I-CDR binding and for brain adenylate cyclase activation by CDR. © 1978.
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页码：1076 / 1081
页数：6
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