STRAIN DIFFERENCES IN IMMUNE-RESPONSE OF MICE TO HOMOLOGOUS SPERM-SPECIFIC LACTATE-DEHYDROGENASE (LDH-C4)

被引：14

作者：

KILLE, JW ^{[1
]}

WHEAT, TE ^{[1
]}

MITCHELL, G ^{[1
]}

GOLDBERG, E ^{[1
]}

机构：

[1] ROYAL MELBOURNE HOSP,WALTER & ELIZA HALL INST MED RES,EXPTL PATHOL UNIT,MELBOURNE 3050,VICTORIA,AUSTRALIA

来源：

JOURNAL OF EXPERIMENTAL ZOOLOGY | 1978年 / 204卷 / 02期

关键词：

D O I：

10.1002/jez.1402040213

中图分类号：

Q95 [动物学];

学科分类号：

071002 ;

摘要：

The sperm‐specific isozyme of murine lactate dehydrogenase (LDH‐C4 was injected into female mice of various strains. Two regulatory phenotypes characterize the resultant immunity to LDH‐C4: one is manifested by high, intermediate or low levels of response, the other by the immediate or delayed maturation of peak titer. The response of several strains can be classified as high (SWR, SJL, BABL/c, C3H/He) and intermediate to low (A, CBA, DBA/2, DBA/1, C57BL/6) according to the level of antibody production and cell mediated immunity. BALB/c, SJL and SWR strains are immediate responders while and C3H/He mice are clearly delayed responders. Maturation and magnitude of response do not appear to be related. Both the antibody and cell mediated responses are T‐dependent, but are not obviously associated with Ig allotype or H‐2 regulation. Copyright © 1978 Wiley‐Liss, Inc., A Wiley Company

引用

页码：259 / 265

页数：7

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