MODULATION OF MEMORY FIELDS BY DOPAMINE D1 RECEPTORS IN PREFRONTAL CORTEX

被引：1303
作者：
WILLIAMS, GV
GOLDMANRAKIC, PS
机构：
[1] Section of Neurobiology, Yale University School of Medicine, New Haven, CT
来源：
NATURE | 1995年 / 376卷 / 6541期
关键词：
D O I：
10.1038/376572a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Dopamine has been implicated in the cognitive process of working memory but the cellular basis of its action has yet to be revealed. By combining iontophoretic analysis of dopamine receptors with single-cell recording during behaviour, we found that D1 antagonists can selectively potentiate the 'memory fields' of prefrontal neurons which subserve working memory. The precision shown for D1 receptor modulation of mnemonic processing Indicates a direct gating of selective excitatory synaptic inputs to prefrontal neurons during cognition.
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页码：572 / 575
页数：4
相关论文
共 45 条
[1]  
Amsten A. F., 1995, J NEUROSCI, V15, P3429
[2]   DOPAMINE D-1 RECEPTOR MECHANISMS IN THE COGNITIVE PERFORMANCE OF YOUNG-ADULT AND AGED MONKEYS [J].
ARNSTEN, AFT ;
CAI, JX ;
MURPHY, BL ;
GOLDMANRAKIC, PS .
PSYCHOPHARMACOLOGY, 1994, 116 (02) :143-151
[3]   EFFECTS OF D-AMPHETAMINE AND PREFRONTAL CORTICAL COOLING ON DELAYED MATCHING-TO-SAMPLE BEHAVIOR [J].
BAUER, RH ;
FUSTER, JM .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1978, 8 (03) :243-249
[4]   DOPAMINERGIC INNERVATION OF THE CEREBRAL-CORTEX - UNEXPECTED DIFFERENCES BETWEEN RODENTS AND PRIMATES [J].
BERGER, B ;
GASPAR, P ;
VERNEY, C .
TRENDS IN NEUROSCIENCES, 1991, 14 (01) :21-27
[5]  
BERGSON C, 1994, SOC NEUR ABSTR, V20, P275
[6]   VISUOSPATIAL WORKING MEMORY IN PARKINSONS-DISEASE [J].
BRADLEY, VA ;
WELCH, JL ;
DICK, DJ .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1989, 52 (11) :1228-1235
[7]   COGNITIVE DEFICIT CAUSED BY REGIONAL DEPLETION OF DOPAMINE IN PREFRONTAL CORTEX OF RHESUS-MONKEY [J].
BROZOSKI, TJ ;
BROWN, RM ;
ROSVOLD, HE ;
GOLDMAN, PS .
SCIENCE, 1979, 205 (4409) :929-932
[8]  
BUSHNELL PJ, 1983, PHARM BIOCH BEHAV, V45, P765
[9]   INTRACELLULAR STUDIES ON THE DOPAMINE-INDUCED FIRING INHIBITION OF NEOSTRIATAL NEURONS INVITRO - EVIDENCE FOR D1-RECEPTOR INVOLVEMENT [J].
CALABRESI, P ;
MERCURI, N ;
STANZIONE, P ;
STEFANI, A ;
BERNARDI, G .
NEUROSCIENCE, 1987, 20 (03) :757-771
[10]   NEUROMODULATORY ACTIONS OF DOPAMINE IN THE NEOSTRIATUM ARE DEPENDENT UPON THE EXCITATORY AMINO-ACID RECEPTOR SUBTYPES ACTIVATED [J].
CEPEDA, C ;
BUCHWALD, NA ;
LEVINE, MS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (20) :9576-9580
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