INTERACTION OF CITRUS JUICES WITH FELODIPINE AND NIFEDIPINE

被引：504

作者：

BAILEY, DG

SPENCE, JD

MUNOZ, C

ARNOLD, JMO

机构：

[1] Department of Medicine, Victoria Hospital, University of Western Ontario, N6A4G5, 375 South Street, London, Ontario, Canada

来源：

LANCET | 1991年 / 337卷 / 8736期

关键词：

D O I：

10.1016/0140-6736(91)90872-M

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Six men with borderline hypertension took felodipine 5 mg with water, grapefruit juice, or orange juice. The mean felodipine bioavailability with grapefruit juice was 284 (range 164-469)% of that with water. The dehydrofelodipine/felodipine AUC ratio was lower, diastolic blood pressure lower, and heart rate higher with grapefruit juice than with water. Vasodilatation-related side-effects were more frequent. Orange juice had no such effects. Six healthy men took nifedipine 10 mg with water or grapefruit juice; the bioavailability with grapefruit juice was 134 (108-169)% of that with water.

引用

页码：268 / 269

页数：2

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