Linking autophagy with inflammation through IRF1 signaling in ER+ breast cancer

被引：8
|
作者：
Cook, Katherine L. [1 ,2 ,3 ]
Schwartz-Roberts, Jessica L. [1 ,2 ]
Baumann, William T. [4 ]
Clarke, Robert [1 ,2 ]
机构：
[1] Georgetown Univ, Med Ctr, Dept Oncol, Washington, DC 20007 USA
[2] Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Washington, DC 20007 USA
[3] Wake Forest Univ, Hypertens & Vasc Res Ctr, Wake Forest Comprehens Canc Ctr, Dept Surg, Winston Salem, NC 27109 USA
[4] Virginia Polytech Inst & State Univ, Bradley Dept Elect & Comp Engn, Blacksburg, VA 24061 USA
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2016年 / 3卷 / 01期
关键词：
ATG7; autophagy; breast cancer; estrogen receptor; IRF1 tumor suppressor; unfolded protein response;
D O I：
10.1080/23723556.2015.1023928
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Resistance to antiestrogen therapy remains a critical determinant of mortality in patients affected by ERC breast cancer. Our previous work identified autophagy and interferon regulatory factor 1 (IRF1) signaling as key regulators of this process. We have recently demonstrated a novel reciprocal interaction between IRF1 and ATG7, linking inflammation and autophagy.
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页数：3
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