BIOSYNTHESIS OF RUBROFUSARIN BY FUSARIUM GRAMINEARUM

被引：7

作者：

MOCK, BH

ROBBERS, JE

机构：

[1] The Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, Lafayette, Indiana

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 12期

关键词：

Acetate‐malonate condensation—rubrofusarin formation; Fusarium graminearum—rubrofunarin biosynthesis; Rubrofusarin; biosynthesis—polyketide chain intermediate;

D O I：

10.1002/jps.2600581237

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Using radioactively labeled acetate, evidence was obtained to support the hypothesis that the biosynthesis of rubrofusarin proceeds through a polyketide chain intermediate. It was shown that labeled acetate when diluted with nonlabeled malonate, is preferentially incorporated into the terminal acetate starting unit of the polyketide chain. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1560 / &

共 7 条

[1]

ASHLEY JN, 1937, BIOCHEM J, V31, P386

[2] UBER DEN EINBAU VON NALPHA-METHYLTRYPTOPHAN UND NOMEGA-METHYLTRYPTAMIN IN MUTTERKORNALKALOIDE VOM CLAVIN-TYP [J].

FLOSS, HG ;

GROGER, D .

ZEITSCHRIFT FUR NATURFORSCHUNG PART B-CHEMIE BIOCHEMIE BIOPHYSIK BIOLOGIE UND VERWANDTEN GEBIETE, 1963, B 18 (07) :519-&

[3]

SHIBATA S, 1962, CHEM IND-LONDON, P360

[4]

SIMON H, 1967, ANWENDUNG ISOTOPEN O, V1, P26

[5]

SIMON H, 1967, ANWENDUNG ISOTOPEN O, V1, P13

[6]

TANAKA H, 1961, TETRAHEDRON LETT, P151

[7]

ZENK MH, 1968, LLOYD, V31, P275

← 1 →