SYNTHESIS AND CHARACTERIZATION OF 7-(CH3)(3)N-4-(2,4-(NO2)(2)C6H3S)-NIDO-7-CB10H11 AND ITS BIODISTRIBUTION IN C57B16 MICE BEARING B16 MELANOMA

被引：6

作者：

MORRIS, JH

PETERS, GS

KOLDAEVA, E

SPRYSHKOVA, R

BORISOV, G

机构：

[1] RUSSIAN ACAD MED SCI,ALL RUSSIA CANC RES CTR,MOSCOW,RUSSIA

[2] IV KURCHATOV ATOM ENERGY INST,MOSCOW 123182,RUSSIA

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 1995年 / 9卷 / 04期

关键词：

CARBABORANE; CARBORANE; NEUTRON CAPTURE THERAPY; MELANOMA; BIODISTRIBUTION; BORON;

D O I：

10.1002/aoc.590090405

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

7-(CH3)(3)N-4-{2,4-(NO2)(2)C6H3S}-nido-7-CB10H11 has been synthesized through a Friedel-Crafts substitution reaction on 7-(CH3)(3)N-nido-7-CB10H12. A biodistribution study in mice with implanted B16 melanoma indicates that the compound locates in neoplastic tissue at concentrations which suggest that its use in B-10 neutron capture therapy may be feasible

引用

页码：323 / 325

页数：3

共 11 条

[1]

Morris J.H., (1991)

[2]

(1992)

[3]

Barth R.F., Soloway A.H., Cancer, 70, (1992)

[4]

Khan S.A., Morris J.H., Siddiqui S., (1990)

[5]

Khan S.A., Morris J.H., Harman M., Hursthouse M.B., (1992)

[6]

Morris J.H., Khan S.A., Mair F.S., Peters G.S., Proc. 4th Int. Symp. NCT for Cancer, (1992)

[7]

Mair F.S., Morris J.H., Gaines D.F., Powell D., (1993)

[8]

Tolpin E.I., Wellum G.R., Berley S.A., Inorg. Chem., 17, (1978)

[9]

Selective Activation of Drugs by Redox Processes, (1990)

[10]

Adams G.E., Asquith J.C., Dewey D.L., Foster J.L., Wilson R.L., Int. J. Radiat. Biol., 19, (1971)

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