Inhibition of a plant virus infection by analogs of melittin

被引：48

作者：

Marcos, JF ^{[1
]}

Beachy, RN ^{[1
]}

Houghten, RA ^{[1
]}

Blondelle, SE ^{[1
]}

PerezPaya, E ^{[1
]}

机构：

[1] TORREY PINES INST MOLEC STUDIES, SAN DIEGO, CA 92121 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 26期

关键词：

antiviral; tobacco mosaic virus;

D O I：

10.1073/pnas.92.26.12466

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An approach that enables identification of specific synthetic peptide inhibitors of plant viral infection is reported. Synthetic analogs of melittin that have sequence and structural similarities to an essential domain of tobacco mosaic virus coat protein were found to possess highly specific antiviral activity. This approach involves modification of residues located at positions analogous to those that are critical for virus assembly. The degree of inhibition found correlates well with sequence similarities between the viral capsid protein and the melittin analogs studied as well as with the induced conformational changes that result upon interaction of the peptides and ribonucleic acid.

引用

页码：12466 / 12469

页数：4

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