DNA METHYLATION IN FOLATE-DEFICIENCY - USE OF CPG METHYLASE

被引：228
|
作者：
BALAGHI, M
WAGNER, C
机构：
[1] VANDERBILT UNIV, SCH MED, DEPT BIOCHEM, NASHVILLE, TN 37212 USA
[2] VET ADM MED CTR, NASHVILLE, TN 37203 USA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 193卷 / 03期
关键词：
D O I：
10.1006/bbrc.1993.1750
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Folate deficiency produces a marked decrease in the ration of S-adenosylmethionine to S-adenosylhomocysteine. This ratio regulates the activity of many cellular methylation reactions including that of DNA. We used bacterial CpG mehylase to evaluate the effect of folate deficiency on methylation of DNA from livers of weanling rats fed an amino acid-defined folate deficient diet. After 4 weeks, liver DNA from deficient animals was undermethylated compared with DNA from pair-fed control animals. © 1993 Academic Press, Inc.
引用
收藏
页码：1184 / 1190
页数：7
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