PROTECTIVE EFFECTS OF VITAMIN-E AGAINST BLEOMYCIN-INDUCED GENOTOXICITY IN HEAD AND NECK-CANCER PATIENTS INVITRO

被引：0
作者：
TRIZNA, Z
HSU, TC
SCHANTZ, SP
机构：
[1] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT CELL BIOL,BOX 181,1515 HOLCOMBE BLVD,HOUSTON,TX 77030
[2] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT HEAD & NECK SURG,HOUSTON,TX 77030
[3] MEM SLOAN KETTERING CANC CTR,DEPT HEAD & NECK SURG,NEW YORK,NY 10021
[4] NATL INST ONCOL,DEPT HEAD & NECK SURG,H-1122 BUDAPEST,HUNGARY
来源：
ANTICANCER RESEARCH | 1992年 / 12卷 / 02期
关键词：
GENOTOXICITY; CLASTOGENS; BLEOMYCIN; CHEMOPREVENTION; VITAMIN-E;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The quantitative protective effects of alpha-tocopherol acid and alpha-tocopherol acid succinate on mutagen-induced genotoxicity were studied in human lymphoblastoid cell lines and lymphocytes from cultures of peripheral blood. Both agents showed a dose-dependent protection both in lymphoblastoid cell lines and in lymphocytes of head and neck cancer patients. The concentrations used were in the phatmacologic concentration range of vitamin E. The protection against genetic toxic effects may be an important part of the cancer-protective effects of vitamin E.
引用
收藏
页码：325 / 327
页数：3
相关论文
共 14 条
[1]   MEDICAL USES OF VITAMIN-E [J].
BIERI, JG ;
CORASH, L ;
HUBBARD, VS .
NEW ENGLAND JOURNAL OF MEDICINE, 1983, 308 (18) :1063-1071
[2]   SELENIUM AND VITAMIN-E INHIBIT RADIOGENIC AND CHEMICALLY-INDUCED TRANSFORMATION INVITRO VIA DIFFERENT MECHANISMS [J].
BOREK, C ;
ONG, A ;
MASON, H ;
DONAHUE, L ;
BIAGLOW, JE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (05) :1490-1494
[3]  
CHEN LH, 1988, ANTICANCER RES, V8, P739
[4]   PREDIAGNOSTIC SERUM LEVELS OF CAROTENOIDS AND VITAMIN-E AS RELATED TO SUBSEQUENT CANCER IN WASHINGTON COUNTY, MARYLAND [J].
COMSTOCK, GW ;
HELZLSOUER, KJ ;
BUSH, TL .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1991, 53 (01) :S260-S264
[5]  
GERMAN J, 1983, CHROMOSOME MUTATION
[6]   DIETARY INHIBITORS OF MUTAGENESIS AND CARCINOGENESIS [J].
HAYATSU, H ;
ARIMOTO, S ;
NEGISHI, T .
MUTATION RESEARCH, 1988, 202 (02) :429-446
[7]  
HSU TC, 1990, IN VITRO CELL DEV B, V26, P80
[8]   SENSITIVITY TO GENOTOXIC EFFECTS OF BLEOMYCIN IN HUMANS - POSSIBLE RELATIONSHIP TO ENVIRONMENTAL CARCINOGENESIS [J].
HSU, TC ;
JOHNSTON, DA ;
CHERRY, LM ;
RAMKISSOON, D ;
SCHANTZ, SP ;
JESSUP, JM ;
WINN, RJ ;
SHIRLEY, L ;
FURLONG, C .
INTERNATIONAL JOURNAL OF CANCER, 1989, 43 (03) :403-409
[9]   DETERMINANTS OF SERUM ALPHA-TOCOPHEROL IN FINNISH ADULTS [J].
KNEKT, P ;
SEPPANEN, R ;
AARAN, RK .
PREVENTIVE MEDICINE, 1988, 17 (06) :725-735
[10]   SERUM VITAMIN-E AND RISK OF CANCER AMONG FINNISH MEN DURING A 10-YEAR FOLLOW-UP [J].
KNEKT, P ;
AROMAA, A ;
MAATELA, J ;
AARAN, RK ;
NIKKARI, T ;
HAKAMA, M ;
HAKULINEN, T ;
PETO, R ;
SAXEN, E ;
TEPPO, L .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1988, 127 (01) :28-41
12