Subcutaneous Immunotherapy Improves the Symptomatology of Allergic Rhinitis

被引:1
作者
Lourenco, Edmir Americo [1 ]
Caldeira, Eduardo Jose [2 ]
Fabrega Carvalho, Cesar Alexandre [2 ]
Cunha, Marcelo Rodriques [2 ]
Henriques Carvalho, Marcus Vinicius [3 ]
Passos, Saulo Duarte [4 ]
机构
[1] Fac Med Jundiai, Dept Otorhinolaryngol, Rua Francisco Telles,250-B, BR-13202550 Sao Paulo, Brazil
[2] Fac Med Jundiai, Dept Morphol, Sao Paulo, Brazil
[3] Fac Med Jundiai, Dept Surg, Sao Paulo, Brazil
[4] Fac Med Jundiai, Dept Pediat, Sao Paulo, Brazil
基金
巴西圣保罗研究基金会;
关键词
allergy; rhinitis; hypersensitivity; allergen immunotherapy; injections; subcutaneous; symptoms;
D O I
10.1055/s-0035-1564437
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Introduction The relevance of allergic rhinitis is unquestionable. This condition affects people's quality of life and its incidence has increased over the last years. Objective Thus, this study aims to analyze the effectiveness of subcutaneous injectable immunotherapy in cases of nasal itching, sneeze, rhinorrhea and nasal congestion in allergic rhinitis patients. Methods In the present study, the same researcher analyzed the records of 281 patients. Furthermore, the researchers identified allergens through puncture cutaneous tests using standardized extracts containing acari, fungi, pet hair, flower pollen, and feathers. Then, the patients underwent treatment with subcutaneous specific immunotherapy, using four vaccine vials for desensitization, associated with environmental hygiene. The authors analyzed conditions of nasal itching, sneeze, rhinorrhea, and nasal congestion throughout the treatment, and assigned them with a score ranging from zero (0), meaning absence of these symptoms to three (3), for severe cases. The symptoms were statistically compared in the beginning, during, and after treatment. Results In this study, authors analyzed the cases distribution according to age and the evolution of symptomatology according to the scores, comparing all phases of treatment. The average score for the entire population studied was 2.08 before treatment and 0.44 at the end. These results represent an overall improvement of similar to 79% in symptomatology of allergic rhinitis in the studied population. Conclusion The subcutaneous immunotherapy as treatment of allergic rhinitis led to a reduction in all symptoms studied, improving the quality of life of patients, proving itself as an important therapeutic tool for these pathological conditions.
引用
收藏
页码:6 / 12
页数:7
相关论文
共 33 条
[1]   Injection allergen immunotherapy for asthma [J].
Abramson, Michael J. ;
Puy, Robert M. ;
Weiner, John M. .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2010, (08)
[2]   Prevalences of positive skin test responses to 10 common allergens in the US population: Results from the Third National Health and Nutrition Examination Survey [J].
Arbes, SJ ;
Gergen, PJ ;
Elliott, L ;
Zeldin, DC .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 116 (02) :377-383
[3]  
Baena-Cagnani Carlos E, 2002, Rev Alerg Mex, V49, P181
[4]   Allergen-Specific Immunotherapy in Patients 55 Years and Older: Results and Review of Literature [J].
Baptistella, Eduardo ;
Maniglia, Sergio ;
Malucelli, Diego Augusto ;
Rispoli, Daniel ;
de Silva, Thanara Pruner ;
Tsuru, Fernanda Miyoko ;
Becker, Renata Vecentin ;
Bernardi, Gustavo ;
Dranka, Daniela ;
Ferraz, Bruno .
INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY, 2013, 17 (04) :375-379
[5]   Allergic rhinitis: Direct and indirect costs [J].
Blaiss, Michael S. .
ALLERGY AND ASTHMA PROCEEDINGS, 2010, 31 (05) :375-380
[6]   Allergen immunotherapy: Therapeutic vaccines for allergic diseases - A WHO position paper [J].
Bousquet, J ;
Lockey, R ;
Malling, HJ .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1998, 102 (04) :558-562
[7]  
Calderon M. A., 2007, OTOLARYNGOL HEAD NEC
[8]   Duration of allergen immunotherapy in respiratory allergy: when is enough, enough? [J].
Cox, Linda ;
Cohn, John R. .
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2007, 98 (05) :416-426
[9]   How safe are the biologicals in treating asthma and rhinitis? [J].
Cox L.S. .
Allergy, Asthma & Clinical Immunology, 5 (1)
[10]   Allergy diagnosis, allergen repertoires, and their implications for allergen-specific immunotherapy [J].
Crameri, Reto .
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 2006, 26 (02) :179-+