FUNCTIONAL AND PHENOTYPICAL ANALYSIS OF SUBSETS OF RAT CD4+ T-CELLS

被引：2

作者：

NAGAI, Y

INOBE, M

KIKUCHI, K

UEDE, T

机构：

[1] HOKKAIDO UNIV,INST IMMUNOL SCI,IMMUNOPATHOGENESIS SECT,KITA 15,NISHI 1,KITA KU,SAPPORO,HOKKAIDO 060,JAPAN

[2] SAPPORO MED UNIV,SCH MED,DEPT PATHOL,SAPPORO,HOKKAIDO 060,JAPAN

来源：

MICROBIOLOGY AND IMMUNOLOGY | 1993年 / 37卷 / 08期

关键词：

CD4+ T-CELL SUBSETS; CD45R; CYTOKINE GENE;

D O I：

10.1111/j.1348-0421.1993.tb01685.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rat CD4+ T cells were divided into two distinct subsets by a monoclonal antibody RTH-1 recognizing a unique epitope on rat CD45R. Cellular distribution of OX-22- and RTH-1-defined antigens was the same. However, OX-22 and RTH-1 recognized different epitopes that exist on rat CD45R. The expression of IL-4 gene was detected only in RTH-1low CD4+ T cell subset upon various stimulations. In contrast, the expression of IL-2 and IFN-gamma gene varied depending upon the nature of stimuli. The increased cell surface expression of CD44 was detected in RTH-1high CD4+ T cell subset. Conversely the increased expression of CD2 was detected in RTH-1low CD4 T cell subset. The expression of CD3 and LFA-1 was not significantly different between RTH-1high and RTH-1low subsets.

引用

页码：623 / 632

页数：10

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