PANCREATIC-JUICE PEPTIDES AS POTENTIAL REGULATORS OF REPARATIVE PROCESSES IN THE PANCREAS IN ACUTE AND CHRONIC-PANCREATITIS

The experiments were performed on 34 dogs. The subcutaneous injection of boiled pancreatic juice was established-to increase the survival of dogs in acute destructive pancreatitis (p<0.001) and to decrease the specific volume damage to acinar (p<0.01) and interstitial (p<0.05) pancreatic tissue. It was also shown that boiled pancreatic autojuice exerted the therapeutic effect in chronic pancreatitis complicated by pancreatic fistulas. Five peptide components with a molecular mass from 4168 D to 1000 were discovered in the canine boiled pancreatic juice by liquid high pressure chromatography. Fractions with a molecular mass between 2187 and 1348 were found to correspond to biologically active peptides, in particular to somatostatin. It is assumed that the therapeutic effect of boiled pancreatic juice used in acute pancreatitis may be due to somatostatin. Apparently pancreatic juice may turn an efficient therapeutic agent in acute pancreatitis and pancreatic fistulas.