THE HUMAN ENDOGENOUS RETROVIRUS ERV-3 IS UP-REGULATED IN DIFFERENTIATING PLACENTAL TROPHOBLAST CELLS

被引：103

作者：

BOYD, MT ^{[1
]}

BAX, CMR ^{[1
]}

BAX, BE ^{[1
]}

BLOXAM, DL ^{[1
]}

WEISS, RA ^{[1
]}

机构：

[1] QUEEN CHARLOTTES MATERN HOSP, ROYAL POSTGRAD MED SCH, INST OBSTET & GYNAECOL, LONDON W6 0XG, ENGLAND

来源：

VIROLOGY | 1993年 / 196卷 / 02期

关键词：

D O I：

10.1006/viro.1993.1556

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The single copy endogenous retrovirus locus ERV-3 is known to be primarily expressed in the placenta. The absence of expression of this gene in choriocarcinoma cell lines has led to speculation that this may be a defect associated with this abnormality. We show here that ERV-3 is not normally expressed in the cytotrophoblast from which these tumour cells are derived but is expressed in normal syncytiotrophoblast. The conservation of the ERV-3 open reading frame for env in ape and old world monkey species and its tight regulation and site of expression suggest a functional role for this gene in this tissue. © 1993 Academic Press. All rights reserved.

引用

页码：905 / 909

页数：5

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