Data describing the effect of DRD4 promoter polymorphisms on promoter activity

被引：3

作者：

Tei, Shoin ^{[1
]}

Mitsuhashi, Hiroaki ^{[1
]}

Ishiura, Shoichi ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Arts & Sci, Dept Life Sci, Meguro Ku, 3-8-1 Komaba, Tokyo, Japan

来源：

DATA IN BRIEF | 2016年 / 7卷

关键词：

D O I：

10.1016/j.dib.2016.03.084

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This data article tested whether polymorphisms within the dopamine D4 receptor (DRD4) gene promoter can lead to differences in the promoter activity. The variants, a 120-bp variable number tandem repeat (VNTR), 906 T/C, 809 G/A, 616G/C, and - 521C/T, were introduced into the DRD4 promoter and the promoter activity was measured in a neural cell line using the luciferase assay. However, no differences were detected among the haplotypes investigated, and the in vitro data obtained from our protocol could not support the involvement of DRD4 promoter polymorphisms in heritable human traits. (C) 2016 The Authors. Published by Elsevier Inc.

引用

页码：1112 / 1117

页数：6

共 5 条

[1] Functional effects of a tandem duplication polymorphism in the 5'flanking region of the DRD4 gene [J].