XANTHINE-OXIDASE CONTRIBUTES TO LUNG LEAK IN RATS SUBJECTED TO SKIN BURN

被引：11

作者：

BURTON, LK

VELASCO, SE

PATT, A

TERADA, LS

REPINE, JE

机构：

[1] Webb-Waring Institute for Biomedical Research, University of Colorado Health Sciences Center, Denver, 80262, Colorado

来源：

INFLAMMATION | 1995年 / 19卷 / 01期

关键词：

D O I：

10.1007/BF01534378

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We found that rats subjected to thermal skin injury (skin burn) had increased serum xanthine oxidase (XO) activities, increased serum complement activation (decreased serum CH50 levels), increased erythrocyte (RBC) fragility, increased lung neutrophil accumulation, and increased lung leak compared to sham-treated rats. Treatment of rats with allopurinol (an XO inhibitor) not only decreased serum XO activity, but also decreased complement activation, RBC fragility, lung neutrophil accumulation, and lung leak abnormalities in rats subjected to skin burn. We conclude that XO may contribute to acute lung injury and a number of events associated with the development of acute lung leak following skin burn.

引用

页码：31 / 38

页数：8

共 21 条

[1] XANTHINE-OXIDASE PRODUCES HYDROGEN-PEROXIDE WHICH CONTRIBUTES TO REPERFUSION INJURY OF ISCHEMIC, ISOLATED, PERFUSED RAT HEARTS [J].

BROWN, JM ;

TERADA, LS ;

GROSSO, MA ;

WHITMANN, GJ ;

VELASCO, SE ;

PATT, A ;

HARKEN, AH ;

REPINE, JE .

JOURNAL OF CLINICAL INVESTIGATION, 1988, 81 (04) :1297-1301

[2]

BURTON LK, 1989, CLIN RES, V37, pA145

[3]

FRIEDL HP, 1989, AM J PATHOL, V135, P203

[4] LUNG MYELOPEROXIDASE AS A MEASURE OF PULMONARY LEUKOSTASIS IN RABBITS [J].

GOLDBLUM, SE ;

WU, KM ;

JAY, M .

JOURNAL OF APPLIED PHYSIOLOGY, 1985, 59 (06) :1978-1985

[5]

GROSSO MA, 1989, SURGERY, V106, P310

[6]

Grum C.M., 1987, J CRIT CARE, V2, P22

[7] THERMAL-INJURY, INTRAVASCULAR HEMOLYSIS, AND TOXIC OXYGEN PRODUCTS [J].

HATHERILL, JR ;

TILL, GO ;

BRUNER, LH ;

WARD, PA .

JOURNAL OF CLINICAL INVESTIGATION, 1986, 78 (03) :629-636

[8] INCREASED SERUM CATALASE ACTIVITY IN RATS SUBJECTED TO THERMAL SKIN INJURY [J].

LEFF, JA ;

BURTON, LK ;

BERGER, EM ;

ANDERSON, BO ;

WILKE, CP ;

REPINE, JE .

INFLAMMATION, 1993, 17 (02) :199-204

[9] SERUM ANTIOXIDANTS AS PREDICTORS OF ADULT RESPIRATORY-DISTRESS SYNDROME IN PATIENTS WITH SEPSIS [J].

LEFF, JA ;

PARSONS, PE ;

DAY, CE ;

TANIGUCHI, N ;

JOCHUM, M ;

FRITZ, H ;

MOORE, FA ;

MOORE, EE ;

MCCORD, JM ;

REPINE, JE .

LANCET, 1993, 341 (8848) :777-780

[10]

LEFF JA, 1991, J LAB CLIN MED, V118, P352

← 1 2 3 →