NOVEL ALKALOIDS FROM THE SPONGE BATZELLA SP - INHIBITORS OF HIV GP120-HUMAN CD4 BINDING

被引：683

作者：

PATIL, AD

KUMAR, NV

KOKKE, WC

BEAN, MF

FREYER, AJ

DEBROSSE, C

MAI, S

TRUNEH, A

FAULKNER, DJ

CARTE, B

BREEN, AL

HERTZBERG, RP

JOHNSON, RK

WESTLEY, JW

POTTS, BCM

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,RES & DEV,DEPT ANALYT SCI,KING OF PRUSSIA,PA 19406

[2] SMITHKLINE BEECHAM PHARMACEUT,RES & DEV,DEPT PHYS & STRUCT CHEM,KING OF PRUSSIA,PA 19406

[3] SMITHKLINE BEECHAM PHARMACEUT,RES & DEV,DEPT CELLULAR BIOCHEM,KING OF PRUSSIA,PA 19406

[4] UNIV CALIF SAN DIEGO,SCRIPPS INST OCEANOG,LA JOLLA,CA 92093

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1995年 / 60卷 / 05期

关键词：

D O I：

10.1021/jo00110a021

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Caribbean sponge Batzella sp. contains a number of guanidine alkaloids, two of which, batzelladines A (1) and B (2), inhibit the binding of HIVgp-120 to CD4 and are therefore potential inhibitors of HIV. In addition to the known metabolites ptilomycalin A (6), ptilocaulin (7), crambescin A (8), crambescidin 800 (9), and crambescidin 816 (10), Batzella sp. contains five new alkaloids, batzelladines A-E (1-5), the structures of which were elucidated by interpretation of spectral data and chemical degradation.

引用

页码：1182 / 1188

页数：7

共 23 条

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