PHENYTOIN TOXICITY ASSOCIATED WITH HYPOALBUMINEMIA IN CRITICALLY ILL PATIENTS

被引：39

作者：

LINDOW, J

WIJDICKS, EFM

机构：

[1] MAYO CLIN & MAYO FDN,ST MARYS HOSP,DEPT NEUROL W84,ROCHESTER,MN 55905

[2] MAYO CLIN & MAYO FDN,ST MARYS HOSP,DEPT PHARM SERV,ROCHESTER,MN

来源：

CHEST | 1994年 / 105卷 / 02期

关键词：

D O I：

10.1378/chest.105.2.602

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Four critically ill patients developed phenytoin toxicity. Hypoalbuminemia or concomitant displacing drugs resulted in an increased fraction of unbound drug. Clinical findings included gradual decrease in level of consciousness and cerebellar signs. Marked phenytoin toxicity can occur in critically ill patients with hypoalbuminemia and can often be detected only by direct measurement of free phenytoin levels.

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收藏

页码：602 / 604

页数：3

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